Vitamin B12 Gene Polymorphisms and Chronic DiseasesAnjali Haloi1 and Debabrata Das2*
- *Corresponding Author:
- Debabrata Das
Research Fellow, Dr. B. Borooah Cancer Institute
Guwahati - 781016, India
E-mail: [email protected]
Received date July 28, 2014; Accepted date September 28, 2014; Published date October 06, 2014
Citation: Das D, Haloi A (2014) Vitamin B12 Gene Polymorphisms and Chronic Diseases. J Nutr Disorders Ther 4:149. doi:10.4172/2161-0509.1000149
Copyright: © 2014 Das D .et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Vitamin B12 or cobalamin is an essential nutrient with important roles in DNA synthesis, repair and methylation. It is also required in the one carbon metabolism pathway to reduce plasma homocysteine concentrations. Several epidemiological studies have indicated that genes and metabolites of the B vitamin-mediated one-carbon metabolic pathway are associated with chronic diseases. This short review describes polymorphisms in the MTHFR, FUT2 and TCN2 genes which have been implicated in cardiovascular diseases and neural tube defects amongst others.