Medicinal Chemistry

Vitamin D and Obesity

Abstract

Khanh vinh quốc LÆ°Æ¡ng and Lan Thi Hoàng Nguyá»…n

Objective: The prevalence of overweight and obesity is considered an important public issue in the United States and is increasing among both children and adults. There is evidence of aberrations in the vitamin D-endocrine system in obese subjects. Therefore, we will review the role of vitamin D in the adipose tissue.
Methods: Review Medline database literature and discuss the relationship between vitamin D status and obesity.
Results: It has been noted that vitamin D deficiency and obesity share many of the same risk factors, including both indirect – environmental factors (nutritional, racial, geographic, seasonal, and exposure to air pollution) -- -- and direct - genetic risk factors (vitamin D receptor, polycystic ovary syndrome, cytochrome P450, locus 20q13, vitamin D-binding protein gene polymorphisms, and aP2 gene). Vitamin D is fat-soluble and stored in adipose tissue. The serum concentration of 25-hydroxyvitamin D3(25OHD3) is inversely correlated with body weight. The vitamin D receptor (VDR) is present in adipose tissue and may contribute to the action of vitamin D and its analogs in adipocytes. 1,25-dihydroxy-vitamin D3 (1,25OHD3) exerts its actions mainly via its high affinity receptor VDR through a complex network of genomic (transcriptional and post-transcriptional) and non-genomic mechanisms.
Conclusion: Vitamin D plays a role in the regulation of adipose tissue. Obese individuals may need higher doses of vitamin D supplementation than do lean individuals to achieve optimal levels of 25OHD3.Calcitriol modulates adipokine expression and inhibits anti-inflammatory cytokine expression. Calcitriol definitely has a role in the human adipose tissue because of its active form of vitamin D3 metabolite, their receptors presented in adipocytes, and itse suppression of PTH levels.