alexa Vitamin D Concentrations are Decreased in Patients with Alopecia Areata
ISSN: 2376-1318

Vitamins & Minerals
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Research Article

Vitamin D Concentrations are Decreased in Patients with Alopecia Areata

Nigar Yilmaz1*, Gamze Serarslan2 and Cumaali Gokce3
1Department of Biochemistry, Faculty of Medicine, Mugla University, Mugla, Turkey
2Department of Dermatology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
3Department of Endocrinology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
Corresponding Author : Nigar Yilmaz, MD
Department of Biochemistry
Mugla University Medical School
48000, Mugla, Turkey
Tel: ++90 252 251 1000
Fax: ++90 252 223 9280
E-mail: [email protected]
Received March 28, 2012; Accepted May 28, 2012; Published May 31, 2012
Citation: Yilmaz N, Serarslan G, Gokce C (2012) Vitamin D Concentrations are Decreased in Patients with Alopecia Areata. Vitam Trace Elem 1:105. doi:10.4172/2167-0390.1000105
Copyright: © 2012 Yilmaz N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Vitamin D has been of increased interest in the role of maintaining immune system balance. Alopecia Areata (AA) is a T-cell mediated autoimmune disease which causes anagen-stage hair follicles. Low concentration of vitamin D may be a risk factor for AA. We aimed to determine vitamin D concentrations in patients with AA. 25-hydroxyvitamin D (25(OH)-D) concentrations and 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) were determined from sera collected from patients with AA (n=42) and healthy controls (n=42). 25(OH)-D and 1,25(OH)2D3 concentrations were measured by ELISA method. The concentrations of both 25(OH)-D and 1,25(OH)2D3 were found to be significantly lower in patients with AA than control group (p<0.001 for each analysis). The results show that there is a significant difference between AA patients and normal subjects in terms of serum vitamin D concentrations. Therefore, it is suggested that vitamin D deficiency may have a role in the setting of AA.

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