alexa Vitamin D Deficiency and its Repletion: A Review of Cur
ISSN: 2167-7921

Journal of Arthritis
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Review Article

Vitamin D Deficiency and its Repletion: A Review of Current Knowledge and Consensus Recommendations

Haroon M* and Fitzgerald O
Department of Rheumatology, St. Vincent’s University Hospital, Ireland
Corresponding Author : Dr. Muhammad Haroon
Department of Rheumatology
St Vincent’s University Hospital
Elm Park, Dublin 4, Ireland
E-mail: [email protected]
Received March 28, 2012; Accepted July 19, 2012; Published July 21, 2012
Citation: Haroon M, Fitzgerald O (2012) Vitamin D Deficiency and its Repletion: A Review of Current Knowledge and Consensus Recommendations. J Arthritis 1:105. doi:10.4172/2167-7921.1000105
Copyright: © 2012 Haroon M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


In last few years we have witnessed an explosion of research revealing the wide spread prevalence of vitamin D deficiency among all ages, communities, and different disease spectrums. Clearly, vitamin D has been shown to have effects beyond its traditional role in mineral metabolisms, which are mediated through the activation of vitamin D receptors distributed in a variety of tissues. There are strong epidemiological links between vitamin D deficiency and chronic diseases and will continue to be a focus of future research. However, this research information has not yet been fully translated into clinical practice. The increased awareness of the level of vitamin D deficiency in the general population and its potential impact on skeletal and extra skeletal health outcomes have highlighted the important need to understand and follow the latest research knowledge in this area. There remains a poor understanding among health professionals as regards the prescribing policy and the provision of appropriate vitamin D supplements. This review will discuss the physiological role of vitamin D, and the available literature on vitamin D deficiency with respect to its definition, associated factors, prevalence, and management recommendations, and the safety of its repletion.


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