Vitamin D Deficiency as a Risk Factor in Non-Squamous Lung Cancer Subgroups - A Preliminary Study
- Corresponding Author:
- Ahmet BK
Dept. of Thoracic Surgery Medicalpark Hospital Fener m. Tekelioglu c No: 7, 07200 Antalya, Turkey
Tel: +90242 3143434
Fax: +90242 314 3030
E-mail: [email protected]
Received Date: April 16, 2016; Accepted Date: May 16, 2016; Published Date: May 20, 2016
Citation: Kargi AB, Demir M, Tasdemir E, Kargi A (2016) Vitamin D Deficiency as a Risk Factor in Non-Squamous Lung Cancer Subgroups - A Preliminary Study. J Clin Respir Dis Care 2:113. doi: 10.4172/2472-1247.1000113
Copyright: © 2016 Kargi AB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: It has been known that smoking is the primary causative factor of lung cancer, but other factors also play roles. Epidemiological studies demonstrate an increase of cancer in people lower exposure to sunlight and which has an impact in the synthesis of active 25(OH)D. The aim of study was to determinate the potential role of 25(OH)D etiologic factor in subtypes of lung cancer. Methods: There were 140 participants of which 100 were men (71.4%) and 40 (28.6%) were women. The study group was 60 lung cancer before any treatment participants (48 male, 12 female) and control group was 80 (52 male, 28 female). The study group was divided into three histologic subtypes; small cell lung cancer (SCLC) (13 pts, 21.7%), squamous cell lung cancer (SqCC) (18 pts, 30%) and non-squamous (23 adenocarcinoma, 6 others; total 29 pts, 48.3%). Results: There was significant difference between smoking and histologic subgroups (p<0.001). While the SCLC (p=0.002) and the SqCC (p<0.001) group had a significantly more pack/year smoking; no difference in non-squamous subgroup (p=0.114). 25(OH)D levels was significantly less in non-squamous cell subgroups (p<0.001). Smoking group has less 25(OH)D levels than non-smoker group significantly (p=0.006). Conclusion: Meanwhile smoking is a risk factor for SCLC and SqCC; in non-squamous subtype 25(OH)D deficiency could be a causative factor. Our findings may be supported with further studies including larger patient populations.