alexa Vitamin D Insufficiency is a Frequent Finding in Pediatric and Adult Patients with Sickle Cell Disease and Correlates with Markers of Cell Turnover | OMICS International | Abstract
ISSN: 2161-0509

Journal of Nutritional Disorders & Therapy
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Research Article

Vitamin D Insufficiency is a Frequent Finding in Pediatric and Adult Patients with Sickle Cell Disease and Correlates with Markers of Cell Turnover

Winters AC1, Kethman W2, Kruse-Jarres R3 and Kanter J4*

1Cincinnati Children's Hospital, Burnet Ave, Cincinnati, OH 45229, USA

2Stanford University, Serra Mall, Stanford, CA 94305, USA

3Tulane University, St Charles Ave, New Orleans, LA 70118, USA

4Medical University of South Carolina, Charleston, SC, USA

*Corresponding Author:
Julie Kanter
Director, Sickle Cell Disease Research
MUSC, 135 Rutledge Avenue, MSC 558
Charleston, SC, 29425, USA
Tel: (843) 876-8483
E-mail: [email protected]

Received date April 14, 2014; Accepted date June 16, 2014; Published date June 18, 2014

Citation: Winters AC, Kethman W, Kruse-Jarres R, Kanter J (2014) Vitamin D Insufficiency is a Frequent Finding in Pediatric and Adult Patients with Sickle Cell Disease and Correlates with Markers of Cell Turnover. J Nutr Disorders Ther 4:140. doi:10.4172/2161-0509.1000140

Copyright: © 2014 Winters AC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Vitamin D insufficiency affects 33%-78% of children and 60-100% of adults with sickle cell disease (SCD). There are no previous reports demonstrating a correlation between vitamin D insufficiency and cell turnover in patients with SCD. We hypothesized that vitamin D insufficiency was prevalent in our SCD population (ages 0-60 years) and would correlate with reticulocyte counts in these patients. We performed a retrospective cross-sectional review of the medical records of 194 patients (ages up to 60 years) with SCD to evaluate their 25-hydroxyvitamin D levels as a  function of red blood cell turnover, patient’s age, number of pain crises, SCD genotype, and Hydroxyurea therapy. Vitamin D insufficiency was present in 88% of children and 96% of adults in our patient cohort. Serum 25-OH vitamin D levels correlated significantly with both age and reticulocyte counts in multiple regression analysis. Furthermore, pediatric HbSS patients had significantly lower 25-OH vitamin D levels than HbSC patients. No significant correlation was found between vitamin D levels and number of pain crises. Based on these findings, vitamin D insufficiency is a function of overall disease severity as manifested by the correlation with reticulocytosis.


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