alexa Vitamin D Status in Pediatric Patients with Osteogenesi
ISSN: 2161-0665

Pediatrics & Therapeutics
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Research Article

Vitamin D Status in Pediatric Patients with Osteogenesis Imperfecta

Muayad Kadhim1, Laurens Holmes1, Michael B. Bober2*, Kenneth J. Rogers1, Anthony Kallur1, Lauren Davey2 and Richard Kruse1

1Department of Orthopaedic Surgery, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA

2Department of Pediatrics, Division of Medical Genetics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA

*Corresponding Author:
Richard W. Kruse
D.O., MBA, 1600 Rockland Road
Wilmington DE 19803
Tel: 302-651-5007
Fax: 302-651-5951
E-mail: [email protected]

Received Date: August 21, 2011; Accepted Date: November 12, 2011; Published Date: November 13, 2011

Citation: Kadhim M, Holmes L, Bober MB, Rogers KJ, Kallur A, et al. (2011) Vitamin D Status in Pediatric Patients with Osteogenesis Imperfecta. Pediatr Therapeut 1:103. doi:10.4172/2161-0665.1000103

Copyright: © 2011 Kadhim M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Osteogenesis Imperfecta (OI) is a heterogeneous genetic disorder causing skeletal fragility. Although there is increasing awareness about the important role of vitamin D in pediatric bone health, specific data regarding vitamin D status are limited and sometimes unavailable in children with musculoskeletal disorders, such as OI. In this study, we aimed to examine the prevalence of vitamin D deficiency, insufficiency and sufficiency in children with OI. We used a retrospective cohort (case-only) study of 61 children diagnosed with OI. The study variables were analyzed using descriptive statistics. 25-hydroxyvitamin D serum levels less than 20 ng/ml were considered deficient, levels between 20–32 ng/ml were considered insufficient, and levels more than 32 ng/ml were considered sufficient. Sixty one patients (31 boys, 30 girls) were classified according to Sillence type (type I, n = 31; type III, n = 14; and type IV, n = 16). Overall, vitamin D insufficiency and deficiency were identified in approximately half of the patients (50.9%). Vitamin D sufficiency was observed in the majority of infants and toddlers from birth to 3 years (n=13, 56.5%) and in children aged 4–10 years (n=12, 57.1%). A minority of children over the age of 10 were vitamin D sufficient (n=5, 29.4%). The majority of Caucasian patients (n=26, 54.2%) were vitamin D sufficient. Sufficient vitamin D levels were more prevalent among type I OI patients (n =19, 61.3%). Type III patients were found to have an equal prevalence of vitamin D insufficiency (n=6, 42.9%) and sufficiency (n=6, 42.9%). Vitamin D insufficiency was most prevalent in type IV (n=8, 50). Patients with an elevated BMI had a higher prevalence of vitamin D insufficiency (n=4, 57.1%). Further studies are recommended to clarify the relationship between vitamin D serum level and BMI in OI patients.

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