alexa Vitamin E in Vitiligo: Toward Solving the Mystery
ISSN: 2376-0427

Dermatology and Dermatologic Diseases
Open Access

Like us on:

Previously: Journal of Pigmentary Disorders

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Vitamin E in Vitiligo: Toward Solving the Mystery

Igor V Korobko1* and Konstantin M Lomonosov2
1VR Foundation, New York, NY, USA
2Department of Skin and Venereal Diseases, Therapeutic Faculty, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Corresponding Author : Igor V Korobko
Penn Plaza, Suite 6205, New York
NY 10119, USA
Tel: 1-212-786-7589
E-mail: [email protected]
Received September 04, 2014; Accepted September 05,2014; Published September 07, 2014
Citation: Korobko IV, omonosov KML (2014) Vitamin E in Vitiligo: Toward Solving the Mystery. Pigmentary Disorders 1:133. doi:10.4172/2376-0427.1000133
Copyright: 2014 Korobko IV, et al. the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Vitiligo is accompanied by oxidative stress which is likely causative for disease onset. Numerous efforts were undertaken to reveal abnormalities in antioxidant system in vitiligo. Vitamin E is one of the major non-enzymatic components of antioxidant system, and several studies addressed a question of vitamin E deficiency in vitiligo, with controversial conclusions on its presence. Aiming to solve this discrepancy, we analyzed plasma vitamin E level in a cohort of non-segmental vitiligo patients. Although we failed to reveal gross plasma vitamin E level abnormalities, our data suggest that there is subgroup of vitiligo patients with low, close to lower reference value, level of plasma vitamin E, while plasma vitamin E level in remaining patients follows that in general population. While this stratification of vitiligo patients’ needs to be confirmed in large-scale studies, existence of a subgroup of vitiligo patients with “low vitamin E” status might reason inconsistency in previous reports on plasma vitamin E concentration in vitiligo patients. Observed lack of acute vitamin E deficiency in vitiligo patients is in line with reported moderate, if any, effect of oral vitamin E supplementation in complex therapy of vitiligo on extent of repigmentation. At the same time, adjuvant to phototherapy oral vitamin E has beneficial effect in terms of faster response, shorter treatment course and less frequently encountered erythema, likely due to coping with photo-oxidative stress elicited by ultraviolet. Finally, patients from “low vitamin E” group might benefit from vitamin E supplementation through maintaining proper antioxidant system balance thus precluding from oxidative stress-triggered disease recurrence due to lowered vitamin E level.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords