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Vitamin K<sub>2</sub> and Bone Quality | OMICS International | Abstract
ISSN: 2376-1318

Vitamins & Minerals
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Special Issue Article

Vitamin K2 and Bone Quality

Toshiro Sato#
Fine Chemical Laboratory, Nakashinden, Fukuroi-city, Shizuoka, Japan
Corresponding Author : Toshiro Sato
Fine Chemical Laboratory
Nakashinden, Fukuroi-city
Shizuoka, Japan
E-mail: [email protected]
Received February 09, 2013; Accepted February 11, 2013; Published February 28, 2013
Citation: Sato T (2013) Vitamin K2 and Bone Quality. Vitam Trace Elem S6:001. doi:10.4172/2167-0390.S6-001
Copyright: © 2013 Sato T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Vitamin K is a cofactor required for post-translational gamma-carboxylation of vitamin K-dependent proteins, including coagulation and anti-coagulation factors; osteocalcin (OC), essential for bone metabolism; and matrix Gla proteins (MGP), an inhibitor of artery calcification. In addition to activation of OC, vitamin K2 induces collagen accumulation in the bone matrix. The principle effects of vitamin K on bone health are not to increase bone mineral density but to promote bone quality and bone strength. Vitamin K2, as menaquinone-7 (MK-7), is the only major vitamin K homolog which can activate OC at nutritional doses. The higher efficacy of MK-7 is due to its better bioavailability and longer half-life compared to other vitamin K homologs. Furthermore, a normal nutritional intake of MK-7 has been shown to activate MGP, which inhibit artery calcification, and has been associated with prevention of cardiovascular diseases. Thus, MK-7 is thought to contribute to calcium homeostasis in arteries as well as bones

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