alexa Voltage Gated Potassium Channel Antibody Encephalitis Associated with Hyperglycemia
ISSN: 2165-7920

Journal of Clinical Case Reports
Open Access

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Case Report

Voltage Gated Potassium Channel Antibody Encephalitis Associated with Hyperglycemia

Benjamin R Kummer1*, Bethany L Johnson Kerner2 and Charles C Esenwa1
1Department of Neurology, Columbia University Medical Center, New York, NY, USA
2College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA
Corresponding Author : Benjamin R Kummer
Department of Neurology
Columbia University Medical Center, 710 W 168th Street
14th Floor, New York, NY, 10032, USA
E-mail: [email protected]
Received November 12, 2014; Accepted December 28, 2014; Published December 31, 2014
Citation: Kummer BR, Johnson Kerner BL, Esenwa CC (2014) Voltage Gated Potassium Channel Antibody Encephalitis Associated with Hyperglycemia. J Clin Case Rep 4:464. doi:10.4172/2165-7920.1000464
Copyright: © 2014 Kummer BR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

A 65-year-old man presented for evaluation of altered mental status, preceded by several months of sleep abnormalities, excessive salivation, and paroxysms of drenching sweats. Despite having no history of diabetes mellitus, he was severely hyperglycemic with a hemoglobin A1C of 11%. Serum tests revealed hyponatremia as well as positive Voltage-Gated Potassium Channel (VGKC) serum antibodies, and EEG showed frequent epileptic discharges originating from the left temporal lobe. He was ultimately diagnosed with VGKC antibody encephalitis and was treated with antiepileptic, anti-diabetic and corticosteroid agents with improvement in his mental status. One year following treatment, he was seizure-free, had returned to his baseline level of function, and had been weaned off both corticosteroids and anti-diabetic medications.

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