Volume Resuscitation in Sepsis
Krzysztof Laudanski* and Hector Martinez-Hernandez
Department of Anesthesiology & Critical Care, University of Pennsylvania, 3400 Spruce St. Philadelphia, PA 19104, USA
- *Corresponding Author:
- Krzysztof Laudanski
Department of Anesthesiology & Critical Care
University of Pennsylvania
3400 Spruce St. Philadelphia
PA 19104, USA
E-mail: [email protected]
Received date: June 25, 2011; Accepted date: September 03, 2011; Published date: September 20, 2011
Citation: Laudanski K, Martinez-Hernandez H (2011) Volume Resuscitation in Sepsis. J Anesthe Clinic Res 4:281. doi: 10.4172/2155-6148.1000281
Copyright: © 2011 Laudanski K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fluid resuscitation in sepsis is the subject of long and complicated debate. Recent research has called into question several entrenched clinical positions. Currently, crystalloid, titrated to specific hemodynamic parameters is the leading modality of resuscitation in early shock. Central venous pressure, mean arterial pressure, and oxygen saturation of mixed venous blood are the indices which measure the adequacy of fluid resuscitation therapy. Lack of more accurate and earlier predictors of sufficient fluid resuscitation precludes even more effective therapeutic measures. In this review we examine the current evidence that drives fluid resuscitation therapy.