alexa Von Willebrand Factor: A Novel Marker of Endothelial Dy
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Research Article

Von Willebrand Factor: A Novel Marker of Endothelial Dysfunction in Clinical Hyperthyroidism Patients

Mohammed AL-Nuzaily1, Lutfi AL-Maktri1, Saleh Bamashmoos1, Samir Taresh1 and Faisal Ali2,3*

1Department of Haematology, Faculty of Medicine and Health Sciences, Sana’a University, Yemen

2Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Metabolism and Genomics Programme, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

3Department of Haematology, Kuwait University Hospital, Faculty of Medicine and Health Sciences, Sana’a University, Yemen

Corresponding Author:
Faisal Ali
Department of Nutrition and Dietetics
Faculty of Medicine and Health Sciences
Metabolism and Genomics Programme
Universiti Putra Malaysia
43400 UPM Serdang, Selangor, Malaysia
Tel: +967773372122
Fax: +967389426769
E-mail: [email protected]

Received May 25, 2013; Accepted August 13, 2013; Published August 15, 2013

Citation: AL-Nuzaily M, Bamashmoos S, Taresh S, AL-Maktri L, Ali F (2013) Von Willebrand Factor: A Novel Marker of Endothelial Dysfunction in Clinical Hyperthyroidism Patients. J Hematol Thromb Dis 1:115. doi: 10.4172/2329-8790.1000115

Copyright: © 2013 AL-Nuzaily M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Hyperthyroidism is associated with altered endothelial dysfunction and increased risk of arterial thromboembolism and cardiovascular disease. Von Willebrand factor (vWF) is a marker of endothelial dysfunction. There is controversy in reports that have been published concerning the concentrations of vWF in hyperthyroidism. The aim of this study was to investigate the plasma vWF levels in clinical hyperthyroid patients, as well as its relationship to thyroid hormones fT3, fT4 and TSH compared to control subjects. In this study forty recently diagnosed, non-treated clinical hyperthyroid patients (f=37, m=3) and twenty normal volunteers control (f=18, m=2) were included, and subjected to determination of plasma vWF by ELISA technique and serum fT3, fT4 and TSH by Elecsys cobas e 601 analyzer. The data was statistically analysed by SPSS-10 and p values less than 0.05 were considered significant. Our results showed that there were a significant increase of vWF, fT4 and fT3 levels by 100%, 285% and 100%, respectively, and a significant decrease of TSH levels by 12.9-folds in hyperthyroid patients than in control group. For vWF (mean ± SD, 252.2 ± 66.4 vs 126.4 ± 29.9%, repectively; p=0.001). vWF was significantly positively correlated with fT4 and negatively correlated with TSH. In conclusion, we confirmed that hyperthyroidism was associated with increased vWF levels, a novel marker of endothelial dysfunction, FT4 levels being a predictive of vWF levels. Endothelial dysfunction could contribute to higher risk for thromboembolic and cardiovascular disease.

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