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Water Ingestion Increases Plasma Somatostatin in the Course of the Osmopressor Response | OMICS International | Abstract
ISSN: 2167-1095

Journal of Hypertension: Open Access
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Research Article

Water Ingestion Increases Plasma Somatostatin in the Course of the Osmopressor Response

Chih-Cherng Lu1*, Yu-Juei Hsu2, You Hsiang Chu3, Herng Sheng Lee4, Tso-Chou Lin1, Shung-Tai Ho5, Che-Se Tung6 and Ching-Jiunn Tseng7

1Department of Anesthesiology, Tri-Service General Hospital, Taiwan

2Nephrology of Internal Medicine, Tri-Service General Hospital, Taiwan

3Institute of Aerospace Medicine, Tri-Service General Hospital, Taiwan

4Pathology, Tri-Service General Hospital, Taiwan

5Department of Anesthesiology (S.T.H.), Taipei Veterans General Hospital, Taiwan

6Department of Physiology, National Defense Medical Center, Taiwan

7Department of Education and Research (C.J.T.), Kaohsiung Veterans General Hospital, Taiwan, Republic of China

*Corresponding Author:
Chih-Cherng Lu
Associate Professor, Department of Anesthesiology
Tri-Service General Hospital/National Defense Medical Center
Room 8113, No. 161, Sec. 6
Minchuan E. Road, Taipei, Taiwan
Tel: 886-2-8792-7125
Fax: 886-2-8792-7130
E-mail: [email protected]

Received Date: March 14, 2013; Accepted Date: March 22, 2013; Published Date: March 24, 2013

Citation: Lu CC, Hsu YJ, Chu YH, Lee HS, Lin TC, et al. (2013) Water Ingestion Increases Plasma Somatostatin in the Course of the Osmopressor Response. J Hypertens 2:114. doi:10.4172/2167-1095.1000114

Copyright: © 2013 Lu CC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Studies in patients with an impaired efferent baroreflex led to the discovery that ingestion of water induces a robust increase in blood pressure and vascular resistance. This response was also present in healthy subjects with intact baroreflexes. We aimed to clarify the physiological role of the osmopressor response by determining the change of plasma somatostatin after water ingestion in young healthy subjects.

Methods and results: In a randomized, controlled, crossover fashion, 17 young healthy subjects (aged 22-35 years) ingested either 500 or 50 mL of water. Heart rate, blood pressure, cardiac index, and total peripheral vascular resistance were measured using a Finometer hemodynamic monitor. Blood sampling was performed at 5 min before and at 25 and 50 min after water ingestion. Plasma somatostatin was measured by ELISA. At 25 min after the ingestion of 500 mL of water, total peripheral resistance increased and plasma osmolality decreased, significantly. Plasma somatostatin increased significantly after ingestion of 500 mL of water, and the magnitude of change in plasma somatostatin strongly correlated with the change in total peripheral vascular resistance.

Conclusions: An increase in plasma somatostatin associated with the drop in osmolality after water ingestion might contribute to the physiology of the osmopressor response.