What are the Implications of Distinct HPV Genotypes in Women of Different Ethnic/Racial Ancestry?
Adriana C. Vidal*, Susan K. Murphy and Cathrine Hoyo
Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham NC 27710, USA
- *Corresponding Author:
- Adriana C. Vidal
Department of Obstetrics and Gynecology
Division of Clinical Epidemiology
Duke University School of Medicine
P.O. Box 104006, Durham, NC 27710, USA
Tel: (919) 681-9391
E-mail: [email protected]
Received date: March 11, 2014; Accepted date: April 26, 2014; Published date: April 26, 2014
Citation: Vidal AC, Murphy SK, Hoyo C (2014) What are the Implications of Distinct HPV Genotypes in Women of Different Ethnic/Racial Ancestry?. J Vaccines Vaccin 5:228. doi:10.4172/2157-7560.1000228
Copyright: © 2014 Vidal AC et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Invasive cervical cancer incidence and mortality continue to disproportionately affect racial/ethnic minorities, and the distribution of HPV genotypes varies by race/ethnicity, providing a potential explanation for such differences in incidence and mortality. It remains unclear whether such differences could be explained by host genetics or epigenetics that increase susceptibility to particular HPV genotypes, viral genetics, differences in HPV genotypes harbored by different social and/or economic networks, or by differences as simply as function of sexual networks. Determining if race-specific vaccines will benefit some subgroups will depend on addressing these questions. In general, it is our opinion that given population admixture, race/ethnicity based vaccine development may have limited value. Necessary to resolving this question will be the deliberate inclusion of minority populations into observational studies and clinical trials, as well as increase efforts in the study of other less racially admixed populations.