alexa Which Skin Lupus Criteria are of More Value in Determining the Disease: A Greater View with the Help of Direct Immune Fluorescent (DIF)
ISSN: 2472-128X

Journal of Clinical & Medical Genomics
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Research Article

Which Skin Lupus Criteria are of More Value in Determining the Disease: A Greater View with the Help of Direct Immune Fluorescent (DIF)

Sahra Emamzadehfard1-3, Alireza Ghannadan1,3* and Sara Pourhassan Shamchi2,4
1Department of Dermatopathology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Department of Radiology, University of Pennsylvania, Philadelphia, USA
3Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
4Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author : Sahra Emamzadehfard, MD
Department of Dermatopathology, Razi Dermatology Hospital
Tehran University of Medical Sciences, Tehran, Iran
Tel: +982155159988
Fax: +982155155050
E-mail: [email protected]
Received: March 11, 2016 Accepted: March 15, 2016 Published: March 26, 2016
Citation: Emamzadehfard S, Ghannadan A, Shamchi SP (2016) Which Skin Lupus Criteria are of More Value in Determining the Disease: A Greater View with the Help of Direct Immune Fluorescent (DIF). J Clin Med Genomics 4:139. doi:10.4172/2472-128X.1000139
Copyright: © 2016 Emamzadehfard S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: Lupus erythematous (LE) describes a spectrum of auto immune disorders, involving whole body (systemic LE) in one end and cutaneous limited LE on the other side. Cutaneous LE mainly diagnosed via clinical manifestations as well as histopathologic examination. According to different pathologic specifications, the aim of present study was to determine which histopathologic criterion is more accurate and practical in diagnosing cutaneous LE. Material and Methods: Samples taken from patients with clinical manifestations of Cutaneous LE with pathologic confirmation, included. All patients had direct immuno fluorescent (DIF) samples that recorded. Histopathologic findings are categorized into three groups: group 1 contains epidermal changes, group 2 includes interface changes and group 3 contains dermal changes. Different histopathologic finding such as perivascular infiltration, follicular atrophy, follicular plaque, and basements membrane thickness and other changes, as well as DIF patterns, were recorded in designed questionnaires to further analysis with SPSS software. Results: Of 145 patients (61.4% female and 38.6% male) in 58.6% DLE was the first clinical diagnosis,23% was the second and in subsequent 4.1%, 1.4% and 0.7% was third, fourth and fifth diagnosis respectively. In 11% of caeses DLE was not among clinical impressions. DIF was positive in 49%. As a whole, superficial perivascular and perifolicular infiltration were observed in 99% of the cases and was the commonest pathologic feature followed by basal vacuolization, peri follicular infiltration and epidermal atrophy. Other pathologic changes were observed with variable rates. Discussion: By grouping histopathologic criterion, it seems that hyperkeratosis and thickening of Basement membrane may be major histologic criterion and peri vascular infiltration, peri follicular infiltration and eccrine gland infiltration, may be minor.

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