White Blood Cell Signaling and Defense Mechanisms in Patients with Diabetes Mellitus Type 2 and Periodontitis
|Jens M. Herrmann* and Jörg Meyle|
|Medical Center for Dental, Oral and Maxillofacial Surgery, Justus Liebig University, snake number 14, 35392, Giessen, Germany|
|Corresponding Author :||Dr. Jens M. Herrmann
Mentor, vice Dean of the School of Dental Medicine and Director of the Department
Medical Center for Dental, Oral and Maxillofacial Surgery
Justus Liebig University, Snake Number 14, 35392, Giessen, Germany
Tel: +49 641 99 46255
Fax: +49 641 99 46189
E-mail: [email protected]
|Received May 13, 2014; Accepted June 18, 2014; Published June 20, 2014|
|Citation: Herrmann JM and Meyle J (2014) White Blood Cell Signaling and Defense Mechanisms in Patients with Diabetes Mellitus Type 2 and Periodontitis. J Clin Trials 4:171. doi:10.4172/2167-0870.1000171|
|Copyright: © 2014 Herrmann JM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
White blood cell membrane and surface structures are affected by the metabolic disorders and complications found in diabetes mellitus. Therefore, cellular activation, signal propagation, intracellular signaling as well as bactericidal effector functions are altered.
Most likely diabetic symptoms can be corrected by the systemic intervention and treatment of the patients (Antidiabetic Therapy/ADT, i.e. anti-diabetic medication, diet and dietetic supervision, physiotherapy and physical exercises). We hypothesize that simultaneously blood cell functions will improve.
Gum diseases like periodontitis have long been associated with and termed complications of uncontrolled diabetes mellitus. Vice versa, after diabetic conditions are corrected, periodontitis treatment will be proven effective, when oral hygiene regimen, full mouth decontamination (FD, i.e. the oral use of topical antiseptics prior and after professional mechanical tooth cleaning, tooth as well as root surface planing, polishing as well as gum and soft tissue decontamination in combination with systemic antibiotics) are performed. To reinforce gum healing, reinfection prevention (RP) as well as supportive periodontal therapy (SPT) will be administered by dental professionals on an individual basis and a detailed schedule.
If periodontal pockets critical for participant's self care are not eliminated by FD including RP and SPT, and niches > 5mm after 6 month persist, patients are informed and offered surgical intervention as indicated for gum disease elimination.