alexa White Rot Fungus (Pleurotus pulmonarius) Cultivated on Lead Contaminated Rice Straw Induced Haematotoxicity and Lead Accumulation in Liver and Kidney of Wistar Rats
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
Open Access

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Research Article

White Rot Fungus (Pleurotus pulmonarius) Cultivated on Lead Contaminated Rice Straw Induced Haematotoxicity and Lead Accumulation in Liver and Kidney of Wistar Rats

Rhoda S. Onifade1, Chibuisi G. Alimba2, Clementina O. Adenipekun1* and Adekunle A. Bakare2

1Department of Botany, Mushroom Biotechnology Unit, University of Ibadan, Nigeria

2Department of Zoology, Cell Biology and Genetics Unit, University of Ibadan, Nigeria

*Corresponding Author:
Clementina O. Adenipekun
Mushroom Biotechnology Unit
Department of Botany, University of Ibadan, Nigeria
Tel: +2348033683516
E-mail: [email protected], [email protected]

Received Date: May 12, 2016; Accepted Date: June 10, 2016; Published Date: June 17, 2016

Citation: Onifade RS, Alimba CG, Adenipekun CO, Bakare AA (2016) White Rot Fungus (Pleurotus pulmonarius) Cultivated on Lead Contaminated Rice Straw Induced Haematotoxicity and Lead Accumulation in Liver and Kidney of Wistar Rats. J Drug Metab Toxicol 7:210. doi:10.4172/2157-7609.1000210

Copyright: © 2016 Onifade RS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



White rot fungi (Pleurotus species) are edible


known for their ability to bioaccumulate contaminants including metals from the environment. There is scarcity of information on the toxic effects of the bioaccumulated metals on organisms at higher trophic levels. In this study, we investigated alterations in haematological indices and erythrocyte morphology and lead bioaccumulation potentials in liver and kidney of Wistar rats fed aqueous extract of Pleurotus pulmonarius cultivated on lead (0, 10, 100, 200, 500 and 1000 mg/L) contaminated rice straw substrate. After 8 weeks of cultivation, mushroom did not


in the 1000 mg/L Pb contaminated rice straw. 1 g of mushroom harvested from each of the remaining concentrations showed significant (p<0.001) increase in Pb concentration. Rats exposed to 0.5 mL of the contaminated mushroom extracts for 30 days, showed decreased leucocyte, erythrocyte, haematocrit, platelet and haemoglobin concentrations. Abnormal erythrocyte morphologies like acanthocytes, schizocytes and tear drop were significantly higher in the Pb treated mushroom fed rats than the control. The kidney and liver of treated rats showed significant (p<0.05) increase in Pb concentration with higher Pb bioaccumulation factor in the kidney than the liver. Also insignificant decrease in body and organ weight was observed in treated rats than the control. Pb accumulation in P. pulmonarius increased liver and kidney Pb


and induce alterations in haematological indices and erythrocyte morphology in rats. This poses public health threat to humans and other tertiary consumers foraging white rot fungi from metal contaminated sites.


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