alexa Willgerodt-Kindler Reaction’s Microwave-Enhanced Synthesis of Thiobenzamides Derivatives in Heterogeneous Acid Catalysis with Montmorillonite K-10
ISSN: 2161-0401

Organic Chemistry: Current Research
Open Access

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Research Article

Willgerodt-Kindler Reaction’s Microwave-Enhanced Synthesis of Thiobenzamides Derivatives in Heterogeneous Acid Catalysis with Montmorillonite K-10

Hyacinthe F. Agnimonhan1*, Léon A. Ahoussi1, Bienvenu Glinma1, Justin M. Kohoudé2, Fernand A. Gbaguidi1, Salomé D. S. Kpoviessi1, Jacques Poupaert3 and Georges C. Accrombessi1

1Laboratory of Physics and Synthesis Organic Chemistry (LaCOPS), Faculty of Sciences and Techniques (FAST), University of Abomey-Calavi, BP: 4521 Cotonou, Benin

2Laboratory of Molecular Interactions and Reactivity Chemical and Photochemical, University Paul Sabatier of Toulouse, France

3Louvain Drug Research Institute (LDRI), School of Pharmacy, University Catholique of Louvain, B1 7203 Av. E. Mounier 72, B-1200 Brussels, Belgium

*Corresponding Author:
Hyacinthe FA
Laboratory of Physics and Synthesis Organic Chemistry (LaCOPS)
Faculty of Sciences and Techniques (FAST)
University of Abomey-Calavi, BP: 4521 Cotonou
Benin
Tel: +22995407273;
E-mail: [email protected]

Received date: April 08, 2016; Accepted date: April 29, 2017; Published date: May 10, 2017

Citation: Agnimonhan HF, . Ahoussi LA, Glinma B, Kohoudé JM, Gbaguidi FA, et al. (2017) Willgerodt-Kindler Reaction’s Microwave-Enhanced Synthesis of Thiobenzamides Derivatives in Heterogeneous Acid Catalysis with Montmorillonite K-10. Organic Chem Curr Res 6: 180. doi: 10.4172/2161-0401.1000180

Copyright: © 2017 Hyacinthe FA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The Willgerodt-Kindler (WK) reaction of is one of most synthesis methods used to access the thioamides. The known to thioamides have made this reaction more attractive in catalytic synthesis methods. Heterogeneous catalysis acid with the montmorillonite K-10 applied to this reaction under activation microwave for the synthesis of phenyl (morpholino) methanethiones derivatives shows that the mixture (aldehyde, sulfur, morpholine and K-10) is not only appropriate, but optimizes the reaction. This solid catalyst was easily separated from the reaction mixture and was recycled at least twice (02) without any loss of activity. Operational simplicity, short reaction times, excellent yields and benign environmental conditions are other advantages of this protocol, thus respecting the principles of green chemistry. Among the thioamides synthesized, 4-(morpholine-4-carbonothioyl)benzoic acid (h) is a novel molecule which to our knowledge has never before been synthesized. We obtained it with a yield of 68%. In summary, we can be concluded that the heterogeneous catalysis acid conditions with the montmorillonite K - 10 favourable to the Willgerodt-Kindler reaction for carbonyl compounds. The structures of thioamides synthesized were characterized and confirmed by highresolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) 1D and 2D (COSY, HSQC, HMBC).

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