alexa Withdrawal from Exposure Reverses Hematotoxicity and Hepatotoxicity Caused by Oral Exposure to Nitrocellulose Thinner in Male Rats
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Withdrawal from Exposure Reverses Hematotoxicity and Hepatotoxicity Caused by Oral Exposure to Nitrocellulose Thinner in Male Rats

Friday E Uboh* and Saviour Ufot

Biochemistry Department, University of Calabar, Nigeria

*Corresponding Author:
Friday E Uboh
Biochemistry Department
Faculty of Basic Medical Sciences
University of Calabar, P.M.B.1115
Calabar, Nigeria
E-mail: [email protected]

Received date: August 1, 2013; Accepted date: October 30, 2013; Published date: November 5, 2013

Citation: Uboh FE, Ufot S (2013) Withdrawal from Exposure Reverses Hematotoxicity and Hepatotoxicity Caused by Oral Exposure to Nitrocellulose Thinner in Male Rats. J Clin Toxicol 3:173. doi: 10.4172/2161-0495.1000173

Copyright: © 2013 Uboh FE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Nitrocellulose thinner (nct) is one of the commonly used industrial chemical solvents. Individuals involved in furniture, paint, automobile manufacture and repairs occupations, and those living around these workplace environments are at the risk of exposure to nct’s constituents ubiquitously released into the environment. Oral exposure to this solvent has been reported to cause haematotoxicity and hepatotoxicity in rat model. This study assessed the impact of withdrawal from exposure, on nct induced-haematotoxicity and hepatotoxicity in male albino Wistar rats. Four groups, of twelve male rats each, were orally exposed to graded concentrations of nct for 28 days. After the 28th day of exposure, six rats in each group were sacrificed and blood samples collected for nct inducedhaematotoxicity and hepatotoxicity analyses. The remaining six rats in each group were withdrawn from exposure for the next 28 days, after which they were sacrificed, blood samples collected and analyzed for any possible recovery effect from exposure-induced haematotoxicity and hepatotoxicity. The results confirmed that exposure of male rats to nct for 28 days caused a significant (P<0.05) concentration-dependent increase in haematotoxic and hepatotoxic indices, compared to the control. However, 28 days withdrawal from exposure produced a significant (P<0.05) reduction in the recorded haematotoxic and hepatotoxic indices, compared to the nct exposed groups. The results obtained for rats withdrawn from exposure were within the same range as those obtained for the control group, indicating that withdrawal from exposure may reverse the haematotoxic and hepatotoxic effects associated with exposure to nct in male rats.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords