Withdrawal from Exposure Reverses Hematotoxicity and Hepatotoxicity Caused by Oral Exposure to Nitrocellulose Thinner in Male Rats
Friday E Uboh* and Saviour Ufot
Biochemistry Department, University of Calabar, Nigeria
- *Corresponding Author:
- Friday E Uboh
Faculty of Basic Medical Sciences
University of Calabar, P.M.B.1115
E-mail: [email protected]
Received date: August 1, 2013; Accepted date: October 30, 2013; Published date: November 5, 2013
Citation: Uboh FE, Ufot S (2013) Withdrawal from Exposure Reverses Hematotoxicity and Hepatotoxicity Caused by Oral Exposure to Nitrocellulose Thinner in Male Rats. J Clin Toxicol 3:173. doi: 10.4172/2161-0495.1000173
Copyright: © 2013 Uboh FE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Nitrocellulose thinner (nct) is one of the commonly used industrial chemical solvents. Individuals involved in furniture, paint, automobile manufacture and repairs occupations, and those living around these workplace environments are at the risk of exposure to nct’s constituents ubiquitously released into the environment. Oral exposure to this solvent has been reported to cause haematotoxicity and hepatotoxicity in rat model. This study assessed the impact of withdrawal from exposure, on nct induced-haematotoxicity and hepatotoxicity in male albino Wistar rats. Four groups, of twelve male rats each, were orally exposed to graded concentrations of nct for 28 days. After the 28th day of exposure, six rats in each group were sacrificed and blood samples collected for nct inducedhaematotoxicity and hepatotoxicity analyses. The remaining six rats in each group were withdrawn from exposure for the next 28 days, after which they were sacrificed, blood samples collected and analyzed for any possible recovery effect from exposure-induced haematotoxicity and hepatotoxicity. The results confirmed that exposure of male rats to nct for 28 days caused a significant (P<0.05) concentration-dependent increase in haematotoxic and hepatotoxic indices, compared to the control. However, 28 days withdrawal from exposure produced a significant (P<0.05) reduction in the recorded haematotoxic and hepatotoxic indices, compared to the nct exposed groups. The results obtained for rats withdrawn from exposure were within the same range as those obtained for the control group, indicating that withdrawal from exposure may reverse the haematotoxic and hepatotoxic effects associated with exposure to nct in male rats.