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ZJXG Decoction Promotes the Expression of Bone Morphogenetic Protein-7 to Enhance Fracture Healing In Rats | OMICS International | Abstract
ISSN: 2167-1222

Journal of Trauma & Treatment
Open Access

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Research Article

ZJXG Decoction Promotes the Expression of Bone Morphogenetic Protein-7 to Enhance Fracture Healing In Rats

Yunliang Guo*, Xiangjie Wang, Yuexing Pan, Zhixian Du and Zhen Zhou
Affiliated Hospital, Qingdao University Medical College, China
Corresponding Author : Yunliang Guo
Affiliated Hospital
Qingdao University Medical College, China
Tel: 86-0532-82911523
Fax: 86-0532-82911840
E-mail: mailto:[email protected]
Received July 16, 2012; Accepted August 01, 2012; Published August 03, 2012
Citation: Guo Y, Wang X, Pan Y, Du Z, Zhou Z (2012) ZJXG Decoction Promotes the Expression of Bone Morphogenetic Protein-7 to Enhance Fracture Healing In Rats. J Trauma Treat 1:142. doi:10.4172/2167-1222.1000142
Copyright: © 2012 Guo Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The aim is to investigate the effects of Zhuang Jin Xu Gu Decoction (ZJXG Decoction) on femoral fracture healing in rats. Femur fractures were generated in fifty male adult Wistar rats by cutting femur transversely at middle point. ZJXG Decoction was administered orally after surgery for 7-14 d. Radiological evaluation or X-ray imaging analysis indicated that the fibrous callus tissue at the femoral fracture-end increased and the fracture line became fuzzy at 7-14 d following treatment with ZJXG Decoction. Hematoxtlin-Eosin (HE) staining showed that the fibrous-granular tissue at the fracture-end changed gradually to fibrous, cartilaginous and osseous callus tissues. immunohistochemical staining and Enzyme Linked Immunobsorbent Assay (ELISA) results showed that BMP-7 in the fibroblasts and osteoblasts of callus and its serum level increased significantly 7-14 d following treatment with ZJXG Decoction. It is concluded that ZJXG Decoction could enhance the fracture healing by up-regulating the expression of BMP-7 in fibroblasts and osteoblasts of callus in rats.

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