alexa Pharmacodynmics| OMICS International| Clinical Pharmacology And Biopharmaceutics

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Pharmacodynamics, the branch of pharmacology concerned with the action of drugs on the physiology or pathology of the body. It is the study of the physiological and biochemical effects of drugs on the body or on microorganisms or parasites inside or on the body and the mechanisms of drug action and also the relationship between concentration of the drug and its effect. The effect of a drug present at the site of action is determined by that drug’s binding with a receptor. Receptors may be present on neurons in the central nervous system (i.e., opiate receptors) to depress pain sensation, to affect the intensity of contraction on cardiac muscle, or even within bacteria to disrupt maintenance of the bacterial cell wall. It includes a) The effect our body has on drugs b) The action of the liver on molecules of drug c) The effect a drug has on our bodies. d) The movement of a drug in the body. Evaluation of Pharmacokinetics/Pharmacodynamics is a diagnostic tool for underlying disease states. The concept of pharmacodynamics has been expanded to include Multicellular Pharmacodynamics (MCPD). MCPD is the study of the static and dynamic properties and relationships between a set of drugs and a dynamic and diverse multicellular 4 dimensional organization. It is the study of the action of a drug on a minimal multicellular system (mMCS), both in vivo and in silico. Networked Multicellular Pharmacodynamics (Net-MCPD) further extends the concept of MCPD to model regulatory genomic networks together with signal transduction pathways, as interacting components in the cell.
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Last date updated on June, 2014

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