|Spinal cord injury (SCI) is a serious health problem with high care costs and involves primary and secondary mechanisms of injury. SCI destroys the local nerve tissues at the injured site by mechanical trauma. The secondary injury can destroy neighbouring nerve tissue that is not involved in the primary injury. The mechanism associated with secondary injury include edema, altered blood flow and changes in microvascular permeability, the secondary injury is the main reason for functional disturbance of neural system. It is the key to curing SCI, the specific link that is susceptible to therapy. This is especially important since drug treatment is an essential part of SCI treatment and recovery and can affect the prognosis. Up till now, the only drug effective for the treatment of acute spinal cord injury is methylprednisolone, even this drug is receiving scepticism from orthopaedics specialists due to its narrow application window and various complications. Therefore, to find a safe and effective drug which can be long-term used has been a hot and difficult problem for many orthopaedic experts.
Anti-Edema Effect of Epigallocatechin against Acute Spinal Cord Injury in Rats and its Correlation with the P38MAPK/NF-Îºb Signaling Pathway: Yue Zhu