alexa Phyto-Oestrogens for Growth Modification – A Novel Therapeutic Possibility | OMICS International
ISSN: 1948-593X
Journal of Bioanalysis & Biomedicine

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Phyto-Oestrogens for Growth Modification – A Novel Therapeutic Possibility

Ricky W K Wong*

University of Hong Kong, Hong Kong

*Corresponding Author:
Ricky W. K. Wong
University of Hong Kong
Hong Kong
Tel: 852-285-905-54
E-mail: [email protected]

Received Date: June 26, 2013; Accepted Date: July 08, 2013; Published Date: July 10, 2013

Citation: Wong RWK (2013) Phyto-Oestrogens for Growth Modification – A Novel Therapeutic Possibility. J Bioanal Biomed 5: 065. doi: 10.4172/1948-593X.1000081

Copyright: © 2013 Wong RWK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Height is not only important to physical health but also to social and psychological well-being. It is widely accepted that growth is assign of health. At all statureisan unattainable dream for many. At present, treatment with growth hormone alone or with growth hormonereleasing factor is the only treatment available. However, long-term treatment with growth hormone has numerous side effects, including rapid progression through puberty and a reduction in bone mineral density [1]. In addition, the need for daily injections makes growth hormone treatment unpopular; therefore, this treatment is reserved for patients with the most severe growth deficiencies.

The current methods for growth enhancement include growth hormone(GH) treatment alone or combined with a gonadotropinreleasing hormone (GnRH) analogue [2]. However, these treatments have several side effects: an increase in the rate of passing the growth spurt period and rapid progress ion through puberty; a reduction in bone mineral density [1]; increases in lean bodyweight, muscle mass and lipid weight; and uncertain short-and long-term benefits [3]. The levels ofinsulin-likegrowthfactor-1(IGF-1) and insulin-like growth factor-binding protein-3(IGFBP-3) can be used as indices to monitor growth [4].

Oestrogens also play a pivotal role in the regulation of normal skeletal growth and maturation in both boys and girls [5]. In both sexes, oestrogen deficiency leads to the absence of a pubertal growth spurt [6].

Phyto-oestrogens are plant-derived nonsteroidal compounds that bind to oestrogen receptors (ERs) and have activities similar to that of oestrogen [7]. Phyto- oestrogens can increase alkaline Phosphatase activity and promote the mineralization of bone in mouse calvariaosteoblast-like cells [8].

Over the years, our team has investigated Traditional Chinese Medicines and the active components of these medicines that enhance bone healing. We have identified several chemicals from plants that have strong bone healing effects. To examine the effects of various agents (e.g.,naringin, statin and quercetin) on bone formation, we have used NewZealand White rabbits with surgically created bone defects in the parietal bone [9-12].

Over the years, our team has investigated Traditional Chinese Medicines and the active components of these medicines that enhance bone healing. We have identified several chemicals from plants that have strong bone healing effects. To examine the effects of various agents (e.g.,naringin, statin and quercetin) on bone formation, we have used NewZealand White rabbits with surgically created bone defects in the parietal bone [9-12].

In addition, to investigate the possibility of modifying jaw growth either by physical or chemical means, we have researched the spheno occipital synchondrosis, which is the growth centre at the base of the skull. We developed an organ-culture technique for the synchondrosisus in gneonatal mice, and we have demonstrated that mechanical tension can enhance growth across the synchondrosis [12,13]. Using the same model, we have demonstrated that quercetin, aphyto-oestrogen commonly found in onions, apples and grapes, enhances bone healing and formation and promotes growth across the synchondrosis [14]. This result suggests a novel therapeutic possibility: growth can be enhanced by a single phytochemical.

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