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Bovine Spongiform Encephalopathy

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  • Bovine Spongiform Encephalopathy

    Bovine spongiform encephalopathy (BSE), regularly known as distraught dairy animals infection, is a lethal neurodegenerative ailment (encephalopathy) in steers that causes a supple degeneration in the cerebrum and spinal line.

  • Bovine Spongiform Encephalopathy

    BSE has a long brooding period, around 2.5 to 8 years, generally influencing grown-up steers at a top age onset of four to five years, all breeds being just as powerless. BSE is brought about by a misfolded protein—a prion. In the United Kingdom, the nation most noticeably bad influenced, more than 180,000 steers have been tainted and 4.4 million butchered.

  • Bovine Spongiform Encephalopathy

    The molecular features of protease-resistant prion protein (PrP(res)) in Western blots of BSE cases diagnosed in Poland with respect to a possible atypical status. Confirmed cases were analyzed by Western blotting with several monoclonal antibodies directed at N-terminal and core epitopes of prion protein (PrP). Most cases showed the classical glycoprofile characterized by the dominance of the di- over the monoglycosylated PrP(res) band, yielding di-/mono- ratios well above 2 and by reactivity with antibodies having their epitopes in bovine PrP region 110-242 (C-type cases). Surprisingly, seven cases of BSE were atypical. Six were classified as L-type based on a slightly lower molecular mass (M(r)) of the non- glycosylated band with respect to C-types and a conspicuously low di-/mono- ratio of glycosylated PrP(res) bands approaching unity. One case was classified as H-type because of a higher M(r) of PrP(res) bands on the blot when compared with C-type cases. A characteristic epitope of H-type PrP(res) occurred in the 101-110 region of PrP for which only antibody 12B2 had a sufficient affinity. The occurrence of atypical cases only in animals 9 years of age and older raises questions about the mechanisms of prion diseases and the origin of BSE.

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