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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous nephropathy
     is quite rare among the general population but is one of the more common glomerular diseases. It is present in every patient with membranous nephropathy and the process affects all glomeruli in both kidneys.

  • Membranous nephropathy

    Disease pathophysiology: 

    The glomeruli are the filtering units of the kidney and there are around one million in each kidney. They are carefully constructed so that the larger proteins in the blood, such as albumin, donot cross the filtering membrane of the glomerulus. The presence of albumin in the urine is a clear signal of glomerular disease.

  • Membranous nephropathy

    Disease statistics:

    Among patients with primary glomerular disease, 29.7% had focal segmental glomerulosclerosis, 20.7% had membranous nephropathy, and 17.8% had IgA nephropathy. Another 9.1% had minimal change disease and 7% had membranoproliferative glomerulonephritis.

     

  • Membranous nephropathy

    Disease treatment:

    Researchers have explored immunosuppressive regimens for patients with IMN in an effort to optimize the balance between efficacy and toxic effects. Current treatment protocols that include corticosteroids in combination with immunosuppressive agents such as chlorambucil or cyclophosphamide (CYC) have demonstrated good efficacy in patients.

     

  • Membranous nephropathy

    Major research on disease:

    Although primary MGN can occur in children, it is typically found in adults, with a peak incidence in the fourth or fifth decade of life. Rituximab in Primary Membranous Nephropathy: First-Line Therapy, Why Not?

     

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