is quite rare among the general population but is one of the more common glomerular diseases. It is present in every patient with membranous nephropathy and the process affects all glomeruli in both kidneys.
The glomeruli are the filtering units of the and there are around one million in each kidney. They are carefully constructed so that the larger in the blood, such as albumin, donot cross the filtering membrane of the glomerulus. The presence of albumin in the urine is a clear signal of glomerular disease.
Among patients with primary glomerular disease, 29.7% had , 20.7% had membranous nephropathy, and 17.8% had IgA . Another 9.1% had minimal change disease and 7% had glomerulonephritis.
Researchers have explored immunosuppressive regimens for patients with IMN in an effort to optimize the balance between efficacy and toxic effects. Current treatment protocols that include corticosteroids in combination with immunosuppressive agents such as chlorambucil or (CYC) have demonstrated good efficacy in patients.
Major research on disease:
Although primary MGN can occur in children, it is typically found in adults, with a peak incidence in the fourth or fifth decade of life. in Primary Membranous Nephropathy: First-Line Therapy, Why Not?