It is a degenerative neurological disorder.Multiple system atrophy effects the nerve cells in specific areas of the brain and it causes problems with movement, balance, and autonomic functions of the body such as bladder control or blood-pressure regulation.MSA is also known as Shy-Drager syndrome. The symptoms of shy-drager are like Parkinson's disease-like symptoms.Currently there is no specific treatment available to cure multiple system atrophy.Physiotherapy can help to manage symptoms.
The prevalence of MSA is very low (1.94 to 4.4/100,000) with a typical age of onset in the 50s. The incidence of disease is independent of gender . Concerning neuropathology, MSA is an alpha-synucleinopathy . Coexistence of Parkinson’s symptoms with considerable autonomic dysfunction is referred to as Shy–Drager syndrome, after Dr. Milton Shy and Dr. Glenn Drager who identified it in 1960. However, it was redefined as MSA with autonomic phenomena in 1996 .