Polycythemia Vera

Speaker PPTs

• Sujeewa Gunaratne
  Challenges in Consumer Behaviour Change based on Colour Coding System for Beverages as a NCD Control Mechanism in Sri Lanka
  PPT Version | PDF Version
• Emanuele Corongiu
  Role of percutaneous tibial nerve stimulation in the treatment of neurogenic overactive bladder syndrome.
  PPT Version | PDF Version
• Yosef Yarden
  Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
  PPT Version | PDF Version
• Anna Chrobok
  Recoverable and recyclable catalysts for sustainable chemical processes
  PPT Version | PDF Version
• Amila Orucevic
  Prognostic value of ER, PR, and HER2 breast cancer biomarkers and AJCC’s TNM staging system on overall survival of Caucasian females with breast cancer: An institution’s 10 year experience
  PPT Version | PDF Version
• S Karthikeyan
  Resveratrol modulates expression of ABC transporters in non-small lung cancer cells: Molecular docking and gene expression studies
  PPT Version | PDF Version
• Nihat Akin
  Probiotic beverage from black carrot juice fermented with Lactobacillus casei
  PPT Version | PDF Version
• Tony Ifeanyi Ojiezeh
  Haemogram and serum enzymes activities of Newcastle Disease Virus challenged broiler chickens following supplemental treatment with Aloe vera extract.
  PPT Version | PDF Version
• Charbell M.H. Kury
  Real-life challenges in implementing public strategies for HPV vaccination in developing countries, and strategies to increase immunization coverage
  PPT Version | PDF Version