Pathophysiology: Little is known about the route and the source of transmission of the virus. VZV is certainly transmissible through the airborne route and does not require close personal contact. The skin lesions are certainly full of infectious virus particles whilst in contrast, it is almost impossible to isolate virus from the upper respiratory tract. It is possible that aerial transmission originates from symptomless oral lesions.
Disease statistics: Review admissions to Infectious Disease Hospital 65% of 1690 hospital admissions were due to VZV infection (91% varicella and 9% HZ. Mean age 33 years, range 3 days to 94 years; 69% were 11-40 years.
Treatment: Several studies indicate that antiviral medications decrease the duration of symptoms and the likelihood of postherpetic neuralgia, especially when initiated within 2 days of the onset of rash. In typical cases that involve individuals who are otherwise healthy, oral acyclovir may be prescribed.
Research: Seroprevalence of varicella-zoster virus in Polish population