alexa Preventing Muscle Atrophy with Protein and Amino Acid Supplementation | Open Access Journals
ISSN: 2161-0673
Journal of Sports Medicine & Doping Studies
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Preventing Muscle Atrophy with Protein and Amino Acid Supplementation

Jennifer Bunn*

Department of Exercise Science, Campbell University, North Carolina, USA

*Corresponding Author:
Dr. Jennifer Bunn
PhD, Department of Exercise Science,
Campbell University, PO Box 414
Buies Creek, NC 27506, USA
Tel: 910-893-1361
E-mail: [email protected]

Received Date: April 29, 2012; Accepted Date: April 30, 2012; Published Date: May 02, 2012

Citation: Bunn J (2012) Preventing Muscle Atrophy with Protein and Amino Acid Supplementation. J Sports Med Doping Stud 2:e108. doi: 10.4172/2161-0673.1000e108

Copyright: © 2012 Bunn J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Sports Medicine & Doping Studies

There is strong evidence supporting the role of protein and Amino Acid (AA) supplementation in the prevention of muscle protein breakdown and augmentation of muscle protein synthesis when ingested at both pre- and post-exercise [1-5]. Specifically, chronic protein and AA supplementation in conjunction with strength training has been linked to increased strength, power, myofribrillar protein, and myosin heavy chain I and IIa expression [5,6]. Acute protein and AA supplementation has also been shown to attenuate muscle proteolysis caused by endurance exercise [7]. Collectively, these data indicate that protein and AA supplementation may increase protein synthesis and decrease the protein degradation occurs with varying types of exercise. This evidence leads to the question of the potential effects of protein and AA supplementation in preserving skeletal muscle during times of injury, immobilization, and disuse.

In all forms of muscle atrophy there appears to be a shift in the balance between synthesis and degradation, but during unloading and disuse conditions, the decrease in protein synthesis appears to drive the loss of muscle mass, while the rate of protein degradation remains fairly constant [8,9]. However, damage to skeletal muscle caused by injury or damaging eccentric exercises has been shown to activate the ubiquitin proteolytic system to increase protein degradation [10,11]. So in the case of muscle atrophy caused by injury, both an increase in protein degradation and a decrease in protein synthesis occur. Hence, both injury and disuse results in lowered protein synthesis, so protein and AA supplementation may therefore be beneficial.

For injured and eccentric exercise-induced muscle damage, research has shown that the ingestion of protein and AAs induces an anabolic effect in the skeletal muscle resulting in an immediate increase in net protein balance as compared to a placebo group [1,3]. In the specific case of sarcopenia prevention, results showed that the ingestion of essential and nonessential AAs increased muscle protein synthesis, but there was no change in breakdown in both groups [12]. The authors concluded that the essential AAs are primarily responsible for AA-induced protein anabolism in the elderly. Building on this information, researchers evaluated if chronic ingestion of essential AAs for 28 days would help attenuate muscle atrophy and muscle protein breakdown during muscle disuse [13-15]. Protein fractional synthesis rate was higher in the essential AA supplemented group than the placebo group on the first and last day of 28-days of bedrest. Additionally, lean leg mass was maintained throughout bedrest in the essential AA group, but fell in the placebo group, and strength loss was more pronounced in the placebo group compared to the essential AA group. The authors concluded that essential AA supplementation may be a possible intervention in prevention of atrophy as a result of prolonged disuse, and my also play a large role in stimulating muscle protein synthesis. However, a recent study [16] showed that protein and AA supplementation with 28 days of lower leg immobilization was not effective in maintaining leg lean mass or strength when compared to the carbohydrate placebo group.

The aforementioned studies are important in indicating the potential role of protein and AA supplementation in preventing muscle atrophy. However, with the conflicting data, it appears that the effectiveness of supplementation is dependent upon the cause of the atrophy. Protein and AA supplementation appears to be more effective with injury or eccentric exercise-induced muscle damage, and ineffective in some instances of disuse. It may be that when an athlete sustains an injury, it is best to supplement with protein and AAs initially after the damage, prior to atrophy that is caused by disuse during recovery from the injury, but more research exploring the timing of the supplementation is necessary.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

Article Usage

  • Total views: 11897
  • [From(publication date):
    May-2012 - Nov 19, 2017]
  • Breakdown by view type
  • HTML page views : 8084
  • PDF downloads : 3813
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords