"Current research in prion immunology has suggested the possible involvement of multiple cell types of the lymphoreticular system (LRS) during disease progression. Interestingly, almost all cells of the LRS express high levels of PrPCon their surface, which may be a reason why they are involved in the early stages of the disease. Prion accumulation has also been found within granulomas of transgenic mice infected with prions, in lymphoid follicles of kidneys in white-tailed deer infected with the CWD agent ,and has been identified at low levels within the muscle of mule deer infected with the CWD agent and in the muscle tissue of hamsters infected with the TME agent, potentially associated with local inflammation in those tissues .This clearly implicates a role for the immune system as a potential target, if not responder, to the prion agent
(The Immune System in the Pathogenesis and Prevention of Prion Diseases: Furr A, et al.)
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Last date updated on November, 2020