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1, 2, 3-Triazoles As Pharmacophores | 7518
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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1, 2, 3-Triazoles as Pharmacophores

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

Vandana Pore

Accepted Abstracts: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.008

The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of ?click chemistry? due to its reliability, specificity, and biocompatibility. Click chemistry is a modular synthetic approach towards the assembly of new molecular entities. Applications of click chemistry are increasingly found in all aspects of drug discovery. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The synthetic molecules that contain 1,2,3-triazole units show diverse biological activities. The present talk will focus mainly on the recent applications of click reaction in the field of medicinal chemistry, in particular on use of the 1, 2, 3-triazole moiety as pharmacophore.
Vandana Pore received her M. Sc. degree in Organic Chemistry in 1978 from the University of Pune. She then completed her doctoral research at the CSIR-National Chemical Laboratory under the supervision of Dr. Braja Gopal Hazra in the area of synthesis of steroidal plant hormonesbrassinosteroids. The University of Pune awarded her a Ph. D. in 1991. She continued her research career at the CSIR-NCL as a research scientist, working particularly in developing multistep synthetic routes to steroidal molecules such as brassinosteroids, mifepristone, squalamine, and so on. She is the author of more than 50 papers and three US patents. She is an expert reviewer for various journals of international reputation. Her research interests are the design and synthesis of bile acid-based drug molecules.