alexa 2009 H1N1 Pandemic Influenza Virus-like Particle Vaccine Efficacy
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference on Vaccines & Vaccination
July 29-31, 2013 Embassy Suites Las Vegas, NV, USA

Fu Shi Quan
Posters: J Vaccines Vaccin
DOI: 10.4172/2157-7560.S1.017
Abstract
A 2009 H1N1 pandemic influenza virus-like particles (VLPs) vaccine containing HA and M1 proteins derived from the A/California/04/2009 virus was generated. The VLP vaccine efficacy was investigated for efficacy against homologous, heterogous and heterosubtypic influenza viruses in mice. A single intramuscular vaccination provided complete protection against homologous A/California/04/2009 viruses with no virus detected in lungs. For cross protective efficacy against antigenically distant H1N1 viruses, intramuscularly immunized mice were challenged with lethal dose of A/PR8/34 or A/Caledonia/99 viruses after a 2nd boost. Mice showed 100% protection against both viruses. Better cross protection against A/PR8/34 virus than A/Caledonia/20/99 was characterized by lower lung virus titers, less body weight loss, and higher cross reactive recall IgG antibody secreting cell responses. For heterosubtypic immunity, intranasally immunized mice were challenged with lethal doses of H3N2 viruses. Mice showed 100% survival with 10% to 16% body weight losses respectively against A/Philippine/82 or A/ Hong Kong/68 challenge, whereas all na?ve control mice died. Mice showed higher cross reactive lung IgG and IgA responses after H3N2 virus challenges. These results indicate that VLPs can be developed as an effective vaccine which can confer protection against homologous, heterogous and heterosubtypic influenza viruses.
Biography
Fu Shi Quan received her Ph.D. degree at Korea University Seoul, Korea and had postdoctoral training in the laboratory of professor Richard W. Compans (Department of Microbiology & Immunology, School of Medicine, Emory University, GA USA). She has spent most of her scientific career in Dr. Compans? lab studying virus-like particle vaccines. Currently, she is a professor at Kyung Hee University School of Medicine, where her focus is the development of VLP protective vaccines against influenza and a respiratory syncytial virus (RSV). She is recognized as an expert in influenza VLP vaccine research and the development of related mouse models.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version