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The seven natural coumarins are active against human bladder carcinoma cell line EJ. The IC50 values of these coumarins
were collected from the literature and 2D-Quantitative Structure Activity Relationship studies were executed using Easy
QSAR 1.0 tool. Multiple linear regression (MLR) analysis was carried out using the descriptors from PaDEL 2.13 software to
determine the relationship between the structural properties and the anticancer activity. The result of the investigation showed
the contribution of descriptors to the activity. The present study may be helpful for the design of potent inhibitors against human
bladder carcinoma cell line EJ using natural coumarins.
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