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The key advantages of a 3D printed biodegradable scaffolds are custom control of shape, porosity, pore connectivity, material
composition, site-specific drug/growth factor delivery, and orientation. Another limitation in 3D printed parts is that
the mechanical properties of printed objects do not always resemble the repaired tissue in terms of modulus, and strength.
Improvement in mechanical strength often resulted in compromise in biodegradability or biocompatibility. Clinical reported
that porous biphasic bioceramics of hydroxyapatite/β-tricalcium phosphate (Hap/β-TCP) can promote osteoconduction
during new bone formation in in vivo experiments. However, the brittle nature of porous bioceramic substitutes cannot
match the toughness of bone, which limits the use of these materials for clinical load-bearing applications. Fortunately,
our novel methods to enhance mechanical properties are mainly based on the admixture of a combustible reverse negative
thermo-responsive hydrogel (poly(N-isopropylacrylamide base) that burns away during sintering in the resulting object. This
method can be regarded as functioning in a manner similar to the cold isostatic press (CIP) step before the powder sintering
densification process. In other words, sintering densification is expected via free volume contraction, which will increase the
mechanical properties after the formation of the porous bioceramics. We will develop the curved shape bioceramic block
with interpenetrating channels for bone reconstruction. The study aimed to investigate the processing chain, the dimensional
accuracy and the mechanical and physical characteristics of the implants.
Chih-Kuang Wang has completed his PhD from National Cheng Kung University and Post-doctoral studies from Industrial Technology Research Institute (ITRI) in Taiwan. He is a staff member of the Department of Medicinal and Applied Chemistry and also the Investigator working in the Orthopaedic Research Center (ORC) at Kaohsiung Medical University (KMU). He has published more than 40 papers in reputed journals, 5 kinds of patent have been acquired, and 3 kinds of patent application are in process.