70-gene signature (Mamma print®): Assessment using samples fixed in formalin and embedded in paraffin, obtained via diagnostic core-needle biopsies

2^nd World Congress on Breast Cancer

September 19-21, 2016 Phoenix, USA

Juan Antonio Mieza Arana, Jose Antonio Lopez Ruiz and Ignacio Zabalza Estevez

Cruces University Hospital, Spain
PRETEIMAGEN Radiology Centre, Spain
Galdakao General Hospital, Spain

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

Background: According to some authors, there is the possibility of obtaining a valid analysis of the tumor genetic fingerprint using paraffin blocks containing samples obtained via radio-guided large needle biopsy. Methods: We present 15 cases, with samples obtained via echo-guided biopsy with a 12 G needle (3 to 4 samples) through malignant solid masses during the diagnostic procedure. The samples used for examination by Mamma print�?® came from the paraffin blocks used for the conventional histological diagnosis, following assessment by a pathologist. A review of the available literature on this subject was conducted. Results: The number of samples varied from 3 to 4. In 12 cases (80%), we were able to obtain valid samples for Mamma print�?® assessment. The results were â�?�?High Riskâ�? in five cases and â�?�?Low Riskâ�? in seven cases. Conclusion: Upon our experience, the same samples obtained via per-cutaneous biopsy for assessment of suspicious lesions, with a result of malignancy, can be used for the 70-gene prognosis signature assessment (Mamma print�?®).

Biography :

He was Born in 1956, in Barakaldo-Bizkaia (Basque Country), SPAIN.Doctor in Medicine, Basque Country University. Radiologist. Accredited university Professor in Health Sciencies, Basque Country University.Founding member and past President of the “Spanish Society of Breast Imaging” (SEDIM).Founding member of the “European Society of Breast Imaging” (EUSOBI). Founding member and Past-Vicepresident of the “Iberoamerican Society of Breast Imaging” (SIBIM). Founding member and President of the “Basque Society of Breast Diseases”. Author of numerous articles and book chapters about breast diseases.

Email: jonmieza@yahoo.es