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A Descriptive Analysis Of The Hypocretin Cell Transplantation Diminishing Narcoleptic-like Sleep Disturbances In Rats | 5271
ISSN: 2157-7013

Journal of Cell Science & Therapy
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A descriptive analysis of the hypocretin cell transplantation diminishing narcoleptic-like sleep disturbances in rats

International Conference & Exhibition on Cell Science & Stem Cell Research

Eric Murillo-Rodriguez, Oscar Arias- Carrion, Diana Millan-Aldaco, Marcela Palomero-Rivero and Rene Drucker-Col?n

Accepted Abstracts: J Cell Sci Ther

DOI: 10.4172/2157-7013.S1.16

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, sleep fragmentation, and cataplexy. Th is disturbance is related with hypocretin (HCRT) system disruption either defi cient ligand or dysfunction in HCRT receptors. Studies in experimental narcolepsy models include the genetic KO mice and the dog that lacks the receptor or the ligand. Our group has reported the development of a diff erent experimental model. Th e injection into lateral hypothalamus (LH) of the neurotoxin named hypocretin-2-saporin (HCRT2/SAP) destroys the HCRT neurons and diminishes the contents of the peptide in the cerebrospinal fl uid (CSF) and induces narcoleptic-like behaviour in rats as assessed by EEG/EMG means. Th en, if HCRT2/SAP destroys HCRT neurons and leads to narcolepsy, then it is imperative to evaluate whether graft ing HCRT neurons into LH of lesioned rats would revert the sleep abnormalities. Here we report that transplantation of HCRT neurons into LH of HCRT2/SAP lesioned rats improved the sleep alterations.
Eric Murillo-Rodr?guez completed his Ph.D at the age of 28 years from Universidad Nacional Autonoma de Mexico (UNAM). Dr. Murillo-Rodr?guez was postdoctoral fellow at Harvard University School of Medicine from 2001-2004. He was Associate Researcher at Prof. Rene Drucker-Col?n ́s lab at UNAM (2005-2007). Dr. Murillo- Rodr?guez was holding a Full Professor Appointment at Universidad Autonoma de Campeche (Mexico) from 2007-2009 and currently; he is Full Professor at Universidad An?huac Mayab in Merida, Yucat?n (Mexico). Dr. Murillo Rodriguez is part of the review board of journals such as Journal of Neurology, The International Journal of Neuropsychopharmacology, among others. His scienti fi c production includes more than 30 articles published in peer-reviewed scienti fi c journals, 10 chapters in books and numerous participations in domestic and international conferences. Additionally, he is member of several scienti fi c societies, including Society for Neuroscience and Sleep Research Society. Finally, Dr. Murillo Rodr?guez has received academic awards, including the Young Investigator Award given by the World Federation of Sleep Research Societies and the Sleep Research Society. He is a member of the National System of Researchers in Mexico (Level 1)
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