alexa A Genetic History Of Meningococcal Disease In Western Australia | 62842
ISSN: 2327-5073

Clinical Microbiology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

7th Euro Global Summit on Clinical Microbiology and Mycotoxins

Charlene Kahler
University of Western Australia, Australia
Keynote: Clin Microbiol
DOI: 10.4172/2327-5073.C1.026
Abstract
Neisseria meningitidis causes transmissible sepsis and meningitis. Whole genome sequencing (WGS) has identified approximately 11 genetic lineages or clonal complexes of invasive meningococci and numerous separate lineages of nonpathogenic meningococci. Each clonal complex is predominated by a serogroup, A, B, C, Y, W and X, although serogroup switching can occur. In recent years, serogroup switching in clonal complex 11 (cc11) from C to W has resulted in strains causing widespread outbreaks around the world. Preventative vaccines are available for A, C, Y, and W serogroups. A serogroup B vaccine, Bexsero®, was developed based on four antigens: Factor H binding protein (fHbp), Neisserial Heparin Binding Antigen (NHBA), Neisseria adhesin A (NadA) and porin A (PorA). WGS has been used successfully to approximate the vaccine coverage of Bexsero® in various jurisdictions which ranges from 66-91%. WGS was used to examine the history of meningococcal disease in Western Australia since 2000 and the potential for Bexsero® vaccine introduction. From 2000-2006, this region had a serogroup B outbreak caused by cc41/44, which has since declined without intervention to national levels. Until 2015, fluctuations in the presence and prevalence of clonal complexes led to an average Bexsero® coverage of 61% (annual range: 33-78%). However, in 2016, 75% of all disease cases in Western Australia were caused by serogroup W cc11 involving two outbreaks necessitating community vaccinations with the quadrivalent A/C/Y/W vaccine. Surveillance using WGS has identified outbreaks of cc11 caused by similar strains in local regions suggesting that there are smaller regional circulation patterns of disease in local communities.
Biography

Charlene Kahler has completed her PhD studies from the University of Queensland and Post-doctoral studies from Emory University and Monash University. She is currently the Deputy Director of the Marshall Center of Infectious Disease at the University of Western Australia. She is an expert in meningococcal and gonococcal diseases, and has published over 40 research papers in these fields.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]ine.com

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7