A low serum Estradiol/Progesterone ratio in cervical cancer with high risk Hpv infection

Sayan Bhattacharya, Moumit Roy Goswami, Shamayita Banerjee, Priya Banerjee, Shirshendu and R Satish

: J Bioengineer & Biomedical Sci

Abstract :

Though female sex hormones have been implicated in the pathogenesis of cervical cancer, the association of their serum levels with risk of cervical cancer have been inconsistent. This could be due to lack of attempt made so far, to explore the hormonal status in these women. This stimulated us to explore the serum hormonal status (serum Estradiol/Progesterone ratio) and its association with increased risk of cervical cancer among women with high risk Human Papilloma Virus (HPV) infection. We recruited 68 pre-menopausal and 50 post-menopausal women for our study. All women were infected with high risk HPV. Women with High Grade Squamous Intraepithelial Lesions of cervix (HSIL) and squamous cell cervical carcinoma were chosen as cases and women with Low Grade Squamous Intraepithelial Lesions of cervix (LSIL) and chronic cervicitis were chosen as controls. Serum estradiol and progesterone were estimated by Enzyme Linked Immuno sorbent Assay (ELISA). The expression of estrogen receptors (ER) and progesterone receptors (PR) in cervical tissues were estimated by Immunohistochemistry (IHC) and quantified by using H score. Pre-menopausal cases showed a low serum Estradiol/Progesterone ratio when compared to controls. The serum hormonal ratio shared a positive correlation with ER expression and negative correlation with PR expression among pre-menopausal study population. There was neither a significant difference between serum Estradiol/Progesterone ratio nor a correlation between the serum hormonal ratio and their receptors? expression among post-menopausal women, but there was a significant association between minimal ER & enhanced PR expression and post-menopausal cases when compared to controls. Our study shows that low serum Estradiol/Progesterone ratio is significantly associated with increased risk of cervical cancer among HPV infected pre-menopausal women.

Biography :

Dr. R.Satish: completion of MBBS from Dr MGR Medical University and doing post graduation (MD Biochemistry) at Annamalai University. I have presented scientific papers and won prizes at several international conferences and national level Biochemistry Quiz competitions and I have co-authored 3 papers in reputed journals in the field of cancer biology.