alexa A Mucosal Vaccine Against Hepatitis B & Tetanus Infections | 7131
ISSN: 2161-0665

Pediatrics & Therapeutics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

A mucosal vaccine against hepatitis B & tetanus infections

2nd International Conference on Pediatrics & Gynecology

Kalaiyarasi D, Jaganathan KS, Vamsi Krishna M and Krishnakumar D

Posters: J Pediatr Therapeut

DOI: 10.4172/2161-0665.S1.012

Abstract
Introduction: There is a need to develop combinational vaccine to induce strong systemic and mucosal immunity for Hepatitis B & Tetanus infection. Nasal vaccination is a promising alternative choice for conventional parenteral vaccination as it is non- invasive, capable of elicit strong systemic and mucosal immunity, it does not require needles, avoiding the pain and discomfort. The use of combination vaccines is a useful way to overcome the restrictions of multiple injections, especially for starting the immunization series for children behind schedule. Methods: In this study, the potential of combinational microparticle delivery system as nasal vaccine was investigated. Two type of microparticle formulations were prepared by using Hepatitis B Surface Antigen (HBsAg) and Tetanus Toxoid (TT) with PLGA as polymer. Tri Methyl Chitosan was used as a mucoadhesive coating material. The particle size, surface charge, morphology, protein loading efficiency, protein integrity, In vitro release studies, Fluorescence microscopy, In vivo immunological response was performed. Results: The TMC coated PLGA microparticles has an average size of 1-10μ and a positive zeta potential while PLGA microparticles shows negative zeta potential. The protein loading efficiency was found as above 80%. The antigen integrity was retained intact in encapsulated form as well as on release. The coated microparticles shows strong IgA level as compared to Aluminum adsorbed parenteral vaccines. Conclusion: Surface modified PLGA microparticles proved great potential as a nasal delivery system for combinational vaccines where humoral, cellular and mucosal responses are necessary particularly in conditions after bacterial and viral pathogens invade the host through the mucosal surface.
Biography
D. Kalaiyarasi completed her M. Pharmacy in The Tamilnadu Dr.MGR Medical University, Chennai and pursuing Ph.D., in JNT University, Hyderabad. She has published various papers in reputed journals
Leave Your Message 24x7
Top