alexa
Reach Us +1-504-608-2390
A Novel Approach To The Pathogenesis Of Fuchs Corneal Dystrophy | 8444
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

A novel approach to the pathogenesis of Fuchs Corneal Dystrophy

2nd International Conference on Clinical Research Cardiology, Ophthalmology & Dermatology

Alireza Ziaei and Ula Jurkunas

ScientificTracks Abstracts: J Clinic Experiment Ophthalmol

DOI: 10.4172/2155-9570.S1.05

Abstract
Introduction: Takayasu�s arteritis (TA) is a rare idiopathic chronic inflammatory disease of unknown aetiology, resulting in a granulomatous panarteritis of the aorta and its major branches. Case Report: A 56-year-old women was referred to our Hospital for a chest pain perceived as pressure-like in quality without dyspnea. The patient described multiple episodes of intermittent chest pain, fatigue, arthralgias, fever and weight loss of 5 Kg in the last two months. The physical examination and a chest and abdomen CT were unremarkable. She was in normal sinus rhythm without signs of ischemia or other ECG abnormalities. A routine laboratory workup was unremarkable apart from a platelet count of 500,000/Al, C-reactive protein of 15.9 and Hgb 7.4 g/dl. An echocardiographic study showed areas of crescentic thickening and diffuse echolucency of ascending aorta and arch suggestive of diffuse inflammation (Panel A-top). A PET showed an inflammation of the wall of the aorta and subclavian, iliac and femoral arteries (Panel A-bottom). Therefore, diagnosis of early Takayasu�s arteritis was performed. Oral prednisolone (1 mg/Kg/ day) was administered and tapered to 5-10 mg/day in two months; the patient had an excellent clinical response. After three months echocardiographic study (Panel B-top) and PET did not show an inflammation of the aorta and its branches (Panel B-bottom). Discussion: Our case is about a non-typical chest pain considered as a pleuro-pericarditis by echocardiografic study, mainly an inflammation of aortic wall was found. The use of echocardiographic study and high-resolution Doppler ultrasound was very important to discriminate a pleuro-pericarditis from a TA earlier. B-mode ultrasonography clearly demonstrated the characteristic circumferential arterial wall thickening as a �macaroni-like�, diffusely thickened intima-media complex. In our patient we found areas of crescent thickening and diffuse echolucency of ascending aorta and arch suggestive of a diffuse inflammation by an echocardiographic study only. However, to confirm a diagnosis, we performed 1 8 F-FDG-PET to detect pre-stenotic disease in patients presenting with non-specific features commonly associated with TA. We did not perform CT angiography by this technique offers limited imaging of distal aortic branches. The principle advantage of 18 F-FDG-PET is the detection of areas of high glucose metabolic activity in early TA. Indeed, we performed 18 F-FDG-PET for the assessment of disease activity and response to treatment. Our experience suggests that an accurate echocardiographic study and 18 F-FDG-PET in second time, are important new clinical tools for the diagnosis of early TA and these may have a place in the monitoring of disease activity and response to treatment.
Biography
Top