alexa
Reach Us +44-1647-403003
A Novel Oncolytic Modified Measles Virus Is A Promising Candidate For Cancer Therapy | 57379
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences
Share This Page

A novel oncolytic modified measles virus is a promising candidate for cancer therapy

13th Asia-Pacific Oncologists Annual Meeting

Chieko Kai

University of Tokyo, Japan

Keynote: J Cancer Sci Ther

DOI: 10.4172/1948-5956.C1.089

Abstract
Oncolytic virus therapy is a promising therapy for various tumor types. We previously reported that a wild-type measles virus (MV) efficiently infects and shows high oncolytic activity to breast cancer cells. Since wild type MV infects immune cells using signaling lymphocyte activation molecule (SLAM) as a receptor, and causes its pathogenicity in host animals, we generated a recombinant MV selectively unable to use SLAM (rMV-SLAMblind). The rMV-SLAM blind lost infectivity to lymphoid cells, but maintained its infectivity to breast cancer cells using another receptor of MV, PVRL4 (poliovirus receptor related-4)/Nectin-4. Nectin-4 is hardly expressed in other tissues except placenta in healthy adults. Recent studies reported that Nectin-4 expression is up-regulated in various types of tumor cells, including breast cancer and non-small-cell lung cancer, which is the leading cause of cancer-related death. We examined the efficacy of rMV-SLAMblind on various cell lines derived from refractory cancers, in which Nectin-4/PVRL4 was expressed. The virus showed high oncolytic activity against them and also effectively suppressed tumor mass growth in xenotransplanted immunodeficient mice. Thus, rMV-SLAMblind should be a promising candidate of a novel therapeutic agent for caner treatment.
Biography

Chieko Kai is a full Professor and Director of Animal Research Center, Institute of Medical Science, the University of Tokyo since 1999, and is also a Professor of International Research Center for Infectious Diseases, in the same institute. She is a member of Science Council of Japan. Her major interests are mechanisms of pathogenisity of RNA viruses, and to control viral diseases. Her current research focus is on developing a novel cancer therapy using oncolytic viruses by genetic engineering.

Email: [email protected]

Relevant Topics
Top