alexa A P-type ATPase Of Metarhizium Acridum, MaENA1, Modulates The Thermo- And UV- Tolerances Of Conidia Involved In Multiple Mechanisms Of Stress Tolerance Revealed By Digital Gene Expression Profiling | 17950
ISSN: 0974-7230

Journal of Computer Science & Systems Biology
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2nd International Summit on Integrative Biology
August 04-05, 2014 Hilton-Chicago/Northbrook, Chicago, USA

Yuxian Xia
ScientificTracks Abstracts: J Comput Sci Syst Biol
DOI: 10.4172/0974-7230.S1.006
Abstract
In fungi, the P-type ATPase, ENA ATPase, plays a key role in osmotic and alkaline pH tolerance, its functions in thermo- and UV- tolerances have not been explored. Entomopathogenic fungi are naturally widespread with considerable potential in pest control. AP-type ATPase gene from entomopathogenic fungus Metarhizium acridum, MaENA1 , was functionally analyzed by deletion. MaENA1 transcript was induced byNaCl. ΔMaENA1 was less tolerant to NaCl, heat and UV than wild type, with no significant alterations in growth, conidiation and virulence. Digital gene expression profiling of conidial RNAs resulted in 281 differentially expressed genes (DEGs) between WT and ΔMaENA1 . 85 DEGs, mostly (56) down-regulated, were identified to be associated with heat/UV tolerance, including 6 Cytochrome P450 superfamily genes, 35 Oxidoreductase genes, 24 Ion binding genes, 7 DNA repair genes and 5 other genes. In addition, 8 genes were components of stress responsive pathways: Ras-cAMP PKA pathway, RIM101 pathway and 4 pathways of MAPK cascade. These results demonstrated that MaENA1 specifically regulates tolerances to Na+, heat and UV with no effects on other traits including virulence and conidiation in M. acridum , and involves multiple mechanisms of stress tolerance. Hence, MaENA1 has a potential to improve stress tolerances of conidia in entomopathogenic fungi.
Biography
Yuxian Xia (born 1964, Sichuan, China) is a Professor in Microbiology at Chongqing University, China. He received the BS degree from Sichuan Agricultural University, MA degree from Southwest Agricultural University, China, and the PhD in Biochemistry from University of Bath, UK, in 1985, 1991, and 2000 respectively. He has been with Chongqing University since 2001, and has published about 60 scientific papers on the locust Locusta migratoria manilensis and its fungal pathogen Metarhizium acridum . His interest has been directed toward understanding the mechanisms underlying the conidiation, virulence and stress tolerance of entomopathogenic fungus and the immune responses of host insect.
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