Cervical priming using prostaglandins prior to surgical evacuation reduces the risks of cervical injury.
: To compare the effi
cacy of intramuscular Prostodin and intravaginal Misoprostol in cervical dilatation for fi
trimester termination of pregnancy or missed abortion.
Design, Setting, and Participants:
A randomized controlled trail was conducted between November 2008 to August 2010 at
a tertiary care and academic hospital in Southern India. One hundred adult pregnant women up to 12 weeks of gestation, aged
18 to 35 years, opted for medical termination of pregnancy or presented with missed abortion. Fift
y were randomized to receive
intramuscular Prostodin and rest 50 intravaginal Misoprostol.
er randomization to one or another group, patients received deep intramuscular injection of 1 ml Prostodin
(equivalent of 250microgram of carboprost) or 600 microgram of Misoprostol intravaginally.
Primary outcome measure:
Amount of cervical dilatation achieved. Cervical dilatation was measured aft
er 4 hours of drug
administration using Hegar?s dilator.
ere was no signifi
erence in distribution of age (p=0.832), parity (p=0.537), and proportion of missed
abortion and elective medical termination of pregnancy (p=0.368), between two groups. Mean (standard deviation) cervical
dilatation in Misoprostol group was signifi
cant higher and protodin group, 9.2 (3.1) and 7.7 (2.1) cm, respectively (p=0.005).
e mean diff
erence (std. error) between two groups was 1.54 (0.53) cm. Mean (SD) amount of blood loss in Misoprostol group
was 58.8 (20.1) ml which was signifi
cantly higher than Prostodin group, 30 (11.9) ml (p <0.001).
Intravaginal Misoprostol use gives better cervical dilatation when compared to intramuscular Prostodin.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals