alexa A Randomized Phase II/III Study Of Adverse Events Between Sequential (SEQ) Versus Simultaneous Integrated Boost (SIB) Intensity Modulated Radiation Therapy (IMRT) In Nasopharyngeal Carcinoma; Preliminary Result On Acute Adverse Events | 62387
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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International Conference on Oral, Mouth and Throat Cancer

Anussara P. Songthong
King Chulalongkorn Memorial Hospital, Thailand
Posters & Accepted Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.C1.079
Abstract
Background: To investigate acute and late toxicities comparing sequential (SEQ-IMRT) versus Simultaneous Integrated Boost- Intensity Modulated Radiotherapy (SIB-IMRT) in Naso Pharyngeal Carcinoma (NPC) patients. Methods: Newly diagnosed stage I-IVB NPC patients were randomized to receive SEQ-IMRT or SIB-IMRT, with or without chemotherapy. SEQ-IMRT consisted of two sequential radiation treatment plans: 2Gy x 25 fractions to low-risk planning target volume (PTV-LR) followed by 2Gy x 10 fractions to high-risk planning target volume (PTV-HR). In contrast, SIB-IMRT consisted of only one treatment plan: 2.12Gy and 1.7Gy x 33 fractions to PTV-HR and PTV-LR, respectively. Toxicities were evaluated according to CTCAE version 4.0. Results: Between October 2010 and November 2013, 122 eligible patients were randomized between SEQ-IMRT (54 patients) and SIB-IMRT (68 patients). With median follow-up time of 16.8 months, there was no significant difference in toxicities between the two IMRT techniques. During chemoradiation, the most common grade 3-5 acute toxicities were mucositis (15.4% vs 13.6%, SEQ vs SIB, p=0.788) followed by dysphagia (9.6% vs 9.1%, p=1.000) and xerostomia (9.6% vs 7.6%, p=0.748). During the adjuvant chemotherapy period, 25.6% and 32.7% experienced grade 3 weight loss in SEQ-IMRT and SIB-IMRT (p=0.459). One-year overall survival (OS) and progression-free survival (PFS) were 95.8% and 95.5% in SEQ-IMRT and 98% and 90.2% in SIB-IMRT, respectively (p =0.472 for OS and 0.069 for PFS). Conclusion: This randomized, phase II/III trial comparing SIB-IMRT versus SEQ-IMRT in NPC showed no statistically significant difference between both IMRT techniques in terms of acute adverse events. Short-term tumor control and survival outcome were promising.
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