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ISSN: 2161-0444

Medicinal Chemistry
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6th World Congress on Medicinal Chemistry and Drug Design

Gaia Cecchia
Nutrition & Prevention, Italy
Keynote: Med Chem (Los Angeles)
DOI: 10.4172/2161-0444-C1-029
Abstract
Background: Hunger has often components that are conditioned by time, social behavior and sight of food. Blood glucose concentration (BG) is a biomarker of current energy availability and of hunger. Objectives: Investigating whether energy per meal reduction may allow BG to fall to low levels, when feeding behavior is (mostly) unconditioned and can be recognized. Methods: Subjects of experimental group (trained; n=80) were trained to ignore meal times and to pay attention to their earliest sensations of hunger or discomfort, so to measure glucose (blood glucose) with glucometer for two weeks. The control group was untrained; n=78). After 7-week, all subjects were asked to estimate their pre-prandial BG that was simultaneously measured through a glucose auto analyzer. Results: Estimated and measured glycemic values were found to be linearly correlated in the trained group (r=0.82; p=0.0001) but not in the control (untrained) group (r=0.10; p=0.40). Fewer subjects in the trained group were hungry than those in the control group (p=0.001). The 18 hungry subjects of the trained group had significantly lower glucose levels (80.1±6.3 mg/dL) than the 42 hungry control subjects (89.2±10.2 mg/dL; p=0.01). The estimation error of the entire trained group (4.7±3.6%) was significantly lower than that of the control subjects (17.1±11.5%; p=0.0001). Conclusion: Patients could be trained to accurately estimate their blood glucose and to recognize their sensations of initial hunger at low glucose concentrations.
Biography

Gaia Cecchia has done a course in Mathematics from the University of Florence. She graduated in Pharmaceutical Sciences in the year 2012 with a thesis in neuropharmacology with the title: “Memantine and topiramate in association with hypothermia as neuroprotective agents in the neonatal ischemic encephalopathy”. Since 2012, she is working at the ONLUS-No-profit association ‘Nutrition & Prevention’ with Professor Mario Ciampolini.

Email: [email protected]

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