Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Rishu Gupta
AcceptedAbstracts: J Clin Exp Dermatol Res
Background:Psoriasis is a chronic inflammatory skin disease that affects nearly 3% of the US population. Psoriasis has a direct negative impact on a patient�?¯�?¿�?½s psychological, social, and occupational well-being that can result in depression, anxiety, and a significant decrease in quality of life (QoL). The study aims to prospectively assess the quality of life impact of a therapeutic intervention for patients with moderate to severe plaque psoriasis utilizing validated quality of life psychometric instruments. Methods: Patients with moderate to severe plaque psoriasis received 36 weeks of Ustekinumab. Patients were followed every 4 weeks for assessment withquality of life instruments:Psychological General Well Being (PGWB), Work Productivity and Activity Impairment (WPAI), Psoriasis Quality of Life-12 Items (PQOL-12), and Dermatology Life Quality Index (DLQI). Primary endpoints included changes in PQWB score at week 36 from baseline. Results: Patients experiencedsignificant improvement in quality of life measured by changesfrom baseline in PGWB and other psychometric instruments. Conclusion: Patients with untreated moderate to severe psoriasis experience as much impairment in psychological well being as patients with other medical diseases including breast cancer, heart disease, diabetes, and cancer. Introducing a therapeutic intervention can greatly improve the psychological state andquality of life of psoriasis patients to where it is comparable to those with asymptomatic hypertension.
Rishu Gupta is a medical student from the University of Southern California in Los Angeles, California who is taking a clinical research year to investigate dermatological diseases such as psoriasis and eczema. Dr. John Koo is the Vice Chairman of Dermatology at UCSF and is the Director of the Psoriasis Treatment center. Dr. Koo is board certified in both dermatology and psychiatry and specializes in quality of life as it relates to dermatological disorders.