alexa
Reach Us +1-504-608-2390
A Solitary PRR In Innate Immune Defense | 3464
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

A solitary PRR in innate immune defense

International Conference on Clinical & Cellular Immunology

Jeak Ling Ding

Accepted Abstracts: J Clin Cell Immunol

DOI: 10.4172/2155-9899.S1.011

Abstract
The accepted paradigm about innate immune response is a multi-stepped process - from recognition of the invading microbe by pathogen-recognition receptors (PRRs) to signal transduction, to the production of antimicrobial effectors by the immune cells. Contrary to this belief, we found that a PRR can act singly via a direct shortcut process bypassing multiple cascades of reactions. The extracellular respiratory protein acts a solitary frontline defense PRR, eliciting powerful antimicrobial potencies. This innate immune response phenomenon is evolutionarily entrenched. The limulus hemocyanin and the human cell-free hemoglobin take a exploite the intruding microbe?s proteases and PAMPs to produce toxic reactive oxygen species (ROS) that effectively kills the pathogen. However, the cytotoxic free radicals generated are self-damaging to the host. We found that the Hb molecule rapidly reprograms its structure- function to expose multiple dual antimicrobial potencies and the host?s plasma proteins and enzymes simultaneously suppress further Hb-induced redox activity, thus protecting the host from ROS-induced cytotoxicity.
Biography
Jeak Ling Ding completed her PhD at the University of London, UK. She is a Professor at the National University of Singapore, Dy. Executive Director of the NUS Graduate School for Integrative Sciences and Engineering. She has published >300 journal and conference papers; 19 patents, and has served/serves as editorial board member of Immunobiology and American Journal of Clinical and Experimental Immunology.
Top