FA Mohammed1, S S Alsokari1, M E Wagih1, K Alghamdi1, M K Quato2 and S M Saad-Eldin2
Posters-Accepted Abstracts: Metabolomics
This study presents a two-way, single oral dose, two-weeks washout, crossover bioequivalence study carried out on 24 human volunteers to compare the bioavailability of two locally marketed pharmaceutical products containing cefadroxil, namely, droxil suspension (Test product commercially marketed suspension containing 500 mg of cefadroxil per 10 ml, produced by the United Pharmaceutical Manufacturing Company, Amman, Jordan) and ULTRACEFsuspension (Reference product, commercially marketed suspension containing 500 mg of cefadroxil per 10 ml, Produced by BRISTOL Laboratories, USA). The two products were administered to 24 healthy human volunteers under fasting condition. Following drug administration,venous blood samples (8 ml) for determination of cefadroxil were collected pre-dose (0 hours) and at 0.25, 0.5, 0.75, 1, 1.25,1.50, 1.75,2, 2.5,3, 4, 5, 6, 8 and 10 hours after drug administration. Plasma was separated immediately by centrifugation and stored at -20ºC until analysis. Cefadroxil analysis was carried out by a fully developed HPLC assay procedure. The results obtained revealed that the two products were bioequivalent as indicated by the absence of statistical differences in the plasma concentrations or pharmacokinetics parameters of the two products. The two products therefore can be alternatively prescribed.
Metabolomics:Open Access received 895 citations as per Google Scholar report