alexa Aacacetin Inhibits Expression Of Matrix Metalloproteinases In Interleukin 1β-stimulated Fibroblastlike Synoviocytes
ISSN: 2161-0533

Orthopedic & Muscular System: Current Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

3rd International Conference and Exhibition on Orthopedics & Rheumatology
July 28-30, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Li-Dong Wu, Wei-Ping Chen, Zhi-Gao Yang, Peng-Fei Hu and Jia-Peng Bao
Accepted Abstracts: Orthop Muscul Syst
DOI: 10.4172/2161-0533.S1.019
I t is well known that Rheumatoid arthritis (RA) is an autoimmune joint disease in which fibroblast-like synoviocytes (FLSs) play a pivotal role. In the present study, it was investigated the anti-arthritic properties of acacetin in FLSs. The expression of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 were investigated by quantitative real-time polymerase chain reaction (qRT-PCR) and western-blot at gene and protein levels. At the same time, the phosphorylation of mitogen-activated protein kinases (MAPK) was investigated. The DNA binding activity of NF-κB was investigated by electrophoretic mobility shift assay. For the in vivo study, mouse received intragastric administration of acacetin, the symptoms of arthritis in vivo and the histopathological assessment of joints were performed. It was found that acacetin exerted anti-arthritic properties in an adjuvant-induced arthritis mouse model. Obtained data suggest that acacetin possess potential value in the treatment of RA.
image PDF   |   image HTML
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version