Reach Us +441467840001
Active TGFβ Recruits Mesenchymal Stem Cells For Tissue Repair/remodeling | 9604
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Share This Page

Active TGFβ recruits mesenchymal stem cells for tissue repair/remodeling

2nd International Conference on Tissue Science & Regenerative Medicine

Mei Wan, Changjun Li and Gehua Zhen

ScientificTracks Abstracts: J Tissue Sci Eng

DOI: 10.4172/2157-7552.S1.010

T ransforming growth factor (TGF) β is maintained in a sequestered state in extracellular matrix as a latent form, which is considered as a molecular sensor that releases active TGFβ in response to the perturbations of the extracellular matrix. The biological implication of the temporal discontinuity of TGFβ storage in the matrix and its activation is obscure. We show that active TGFβ controls the mobilization and recruitment of (messenchymal stem cells) MSCs to participate in tissue repair and remodeling. MSCs were mobilized into the peripheral blood in response to vascular injury and recruited to the injured sites where they gave rise to both endothelial cells for reendothelialization and myofibroblastic cells to form thick neointima. Intravenously injection of recombinant active TGFβ1 in uninjured mice rapidly mobilized MSCs into circulation. Further, inhibitor of TGFβ type I receptor blocked the mobilization and recruitment of MSCs to the injured arteries. Thus, TGFβ is an injury-activated messenger essential for the mobilization and recruitment of MSCs to participate in tissue repair/remodeling
Mei Wan, MD., Ph.D. is an Associate Professor of the Center for Musculoskeletal Research, Department of Orthopaedic Surgery at Johns Hopkins University School of Medicine. For 15 years, her research focuses on understanding how TGFβ/Smads signaling regulates the behavior of mesenchymal stem cells (B.Sc.s) in tissue homeostasis, repair and remodeling. In particular, we found that active TGFβ can be released from tissue in response to perturbations to the local environment such as bone remodeling and arterial injury. The released active TGFβ stimulates the migration of B.Sc.s to participate in tissue repair or remodeling. Currently, she is an Editorial Board Member for Journal of Bone and Mineral Research and Bone Research